872279-29-3Relevant articles and documents
Optimization and anti-inflammatory evaluation of methyl gallate derivatives as a myeloid differentiation protein 2 inhibitor
Qiu, Yinda,Xiao, Zhongxiang,Wang, Yanyan,Zhang, Dingfang,Zhang, Wenxin,Wang, Guangbao,Chen, Wenbin,Liang, Guang,Li, Xiaokun,Zhang, Yali,Liu, Zhiguo
, (2019/08/27)
Myeloid differentiation protein 2 (MD2) is a co-receptor of toll-like receptor 4 (TLR4) responsible for the recognition of lipopolysaccharide (LPS) and mediates a series of TLR4-dependent inflammatory responses in inflammatory lung diseases including acute lung injury (ALI). Targeting MD2 thus may provide a therapeutic strategy against these lung diseases. In this study, we identified a novel compound 4k with the potent anti-inflammatory activity among 39 methyl gallate derivatives (MGDs). MGD 4k exhibited a high binding affinity to MD2, which in turn prevented the formation of the LPS/MD2/TLR4 complex. In addition, MGD 4k significantly reversed the upregulation of LPS-induced inflammatory mediators such as tumor necrosis factor-α, interleukin-6, intracellular adhesion molecule-1, vascular cell adhesion molecule-1, and monocyte chemoattractant protein-1 in vitro and in vivo. Mechanistically, MGD 4k performed anti-inflammatory function by inactivating JNK, ERK and p38 signaling pathways. Taken together, our study identified MGD 4k as a novel potential therapeutic agent for ALI through inhibiting MD2, inflammatory responses, and major inflammation-associated signaling pathways.
Synthesis of poly(3,4,5-trihydroxybenzoate amide) and poly(3,4,5- trihydroxybenzoate ester) dendrimers from polyphenols and their chemiluminescence
Lee, Yong-Gyun,Song, Ju-Hyun,Lee, Eon-Jin,Lee, Do-Hun,Jung, Dai-Il,Hahn, Jung-Tai
experimental part, p. 2051 - 2054 (2012/09/21)
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