87239-88-1Relevant academic research and scientific papers
Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases
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, (2015/09/22)
The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.
COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES
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, (2012/04/23)
The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.
The role of reversible oxidative addition in selective palladium(0)- catalyzed intramolecular cross-couplings of polyhalogenated substrates: Synthesis of brominated indoles
Newman, Stephen G.,Lautens, Mark
supporting information; experimental part, p. 11416 - 11417 (2010/10/01)
A Pd(0)-catalyzed C-N bond-forming reaction leading to the synthesis of brominated indoles is described. The use of the phosphine ligand PtBu 3 is necessary for reactivity. It is proposed that the bulky ligand serves to prevent inhibition of th
New ruthenium catalysts containing chiral Schiff bases for the asymmetric hydrogenation of acetophenone
Karame, Iyad,Jahjah, Mohamed,Messaoudi, Abdelhalim,Tommasino, M. Lorraine,Lemaire, Marc
, p. 1569 - 1581 (2007/10/03)
A series of new chiral N4-Schiff bases, containing amine or sulfonamide functionalities has been synthesized. Coupled with ruthenium catalysts, these Schiff bases induce interesting results in the hydrogenation of acetophenone: complete conversion and 76% ee were obtained with the catalytic system Ru(PPh3)3Cl2/(1R,2R)-N,N′-bis-(2- p-tosylaminobenzylidene)-1,2-diphenylethylenediamine. A very important phosphine co-ligand effect was observed on both activity and enantioselectivity of the catalysts. However, without the co-ligand, we obtained an enantioselectivity for the (R)-enantiomer, whereas with nonchiral co-ligand an enantioselectivity for the (S)-enantiomer was observed.
Synthesis and Properties of 5,10,15,20-Tetrakis(3,5-di-t-butyl-2-nitrophenyl)porphyrin: Conformational Stabilities of the Respective Atropisomers and Oxygenation Capabilities of the Iron(III) and Manganese(III) Complexes
Miyamoto, T. Ken,Takagi, Shigeru,Hasegawa, Tai,Tsuzuki, Seizi,Takahashi, Eitaro,et al.
, p. 1649 - 1660 (2007/10/02)
The synthesis and properties of new, bulky atropisomeric porphyrins are described.Four atropisomers of 5,10,15,20-tetrakis(3,5-di-t-butyl-2-nitrophenyl)porphyrins has been easily separated and purified by column chromatography.The isomers all have differe
STERICALLY BULKY PORPHYRINS: THE ATROPISOMERS OF TETRAKIS(3,5-DI-TERT-BUTYL-2-NITROPHENYL)PORPHYRIN AND THEIR IRON(III) COMPLEXES
Miyamoto, T. Ken,Hasegawa, Tai,Takagi, Shigeru,Sasaki, Yukiyoshi
, p. 1181 - 1184 (2007/10/02)
A new "bis pocket" porphyrin has been prepared and characterized.Its four geometric isomers (atropisomers) have been separated by chromatography.Each isomer has relatively high conformational stability to light and prolonged heating.Practical utility of t
