87239-97-2Relevant academic research and scientific papers
Heterocyclic Systems Containing Bridgehead Nitrogen Atom: Syntheses of s-Triazolothiadiazole-6(5H)thiones, s-Triazolothiadiazines and Related Heterocycles
Mohan, Jag,Anjaneyulu, G. S. R.,Kiran
, p. 128 - 131 (2007/10/02)
The reactions of 3-aryl-4-amino-5-mercapto-s-triazoles (II; R = m-Cl-C6H4-, p-MeO-C6H4-, o-CH3-C6H4-, m-CH3-C6H4-, p-CH3-C6H4- and o-Br-C6H4-) with chloroacetic acid, α-haloketones, benzoin, 2,3-dichloroquinoxaline, chloroacetaldehyde diethylacetal and ca
Synthesis of Heterocycles. Part VII . Synthesis and Antimicrobial Activity of Some 7H-s-Triazolothiadiazine and s-Triazolothiadiazole Derivatives
Eweiss, N. F.,Bahajaj, A. A.
, p. 1173 - 1182 (2007/10/02)
The cyclization of 4-amino-5-aryl-3-cyanomethylthio-1,2,4-triazoles II in the presence of concentrated sulfuric acid yields 7H-6-amino-s-triazolothiadiazines III.Cyclization of 4-amino-5-aryl-1,2,4-triazole-3-thiones I with phenacyl chloride yields 7H-3-aryl-6-phenyl-s-triazolothiadiazines IV.Similarly, compounds I condensed with cyanogen bromide, phenyl isothiocyanate and carbon disulfide to give the corresponding cyclized products 6-amino-3-aryl-s-triazolothiadiazoles V, 3-aryl-6-phenylamino-s-triazolothiadiazoles VI and 3-aryl-s-triazolothiadiazol-6(5H)thiones VII, respectively.Also in the presence of phosphoryl chloride, compounds I underwent cyclization with monocarboxylic acids and oxalic acid to 3,6-diaryl-s-triazolothiadiazole VIII and 6,6'-bis(3-aryl-s-triazolothiadiazoles) IX.The above compounds were screened for their antimicrobial activity.
