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ACETALS OF LACTAMS AND ACID AMIDES. 38. SYNTHESIS OF PYRIMIDINE AND PYRIDINE DERIVATIVES ON THE BASIS OF THE REACTION OF ENAMINO AMIDES WITH AMIDE ACETALS
Granik, V. G.,Kaimanakova, S. I.
, p. 657 - 661 (2007/10/02)
Derivatives of 1-benzyl-4-pyrimidinones and 1-benzyl-6-pyrimidinones were synthesized by the reaction of α-cyano-β-N-benzylaminocrotonamide and α-cyano-β-aminocrotonic acid N-benzylamine with dimethylformamide diethylacetal.When 1-benzyl-5-cyano-6-(β-dimethylamino)vinyl-1,6-dihydro-4-pyrimidinone is heated in an alkaline medium, it is converted to 3-cyano-4-benzylamino-2-pyridone, from which a pyridopyrimidine derivative was synthesized.When 1-benzyl-5-cyano-4-(β-dimethylamino)vinyl-1,6-dihydro-6-pyrimidinone is heated in alkaline solution, it is converted to α-cyano-β-hydroxycrotonic acid N-benzylamide.
