872470-62-7Relevant academic research and scientific papers
Trimethylaluminum-assisted alkynylation of nitrones
Bunlaksananusorn, Tanasri,Lecourt, Thomas,Micouin, Laurent
, p. 1457 - 1459 (2007)
Reaction of nitrones with terminal alkynes occurs in the presence of 1 equiv of trimethylaluminum and leads to the corresponding propargylic hydroxylamines in yields ranging from 49 to 90%.
Synthesis of 4-Isoxazolines through Gold(I)-Catalyzed Cyclization of Propargylic N-Hydroxylamines
Chandrasekhar,Ahn, Sewon,Ryu, Jae-Sang
, p. 6740 - 6749 (2016/08/16)
New catalytic methods for the synthesis of 4-isoxazolines have been developed via catalytic intramolecular cyclizations of propargylic N-hydroxylamines. The reactions proceed rapidly in less than 1 h at room temperature in the presence of 5 mol % (PPh3)AuCl/5 mol % AgOTf or 5 mol % (PPh3)AuNTf2. This process features an efficient route to 4-isoxazolines with high yields, short reaction times, and mild reaction conditions.
A Lewis acid/metal amide hybrid as an efficient catalyst for carbon-carbon bond formation
Yamashita, Yasuhiro,Saito, Yuki,Imaizumi, Takaki,Kobayashi, Shu
, p. 3958 - 3962 (2014/10/15)
While Lewis acids and metal amides are among the most frequently used metal species, they are believed to be incompatible when combined. Here we describe a Lewis acid/metal amide hybrid, which contains electron-withdrawing groups and basic and bulky nitro
One-pot stereoselective synthesis of 2-acylaziridines and 2-acylpyrrolidines from N-(propargylic)hydroxylamines
Miyamoto, Yoshiaki,Wada, Norihiro,Soeta, Takahiro,Fujinami, Shuhei,Inomata, Katsuhiko,Ukaji, Yutaka
supporting information, p. 824 - 831 (2013/05/21)
The stereoselective direct transformation of N-(propargylic)hydroxylamines into cis-2-acylaziridines was achieved by the combined use of AgBF4 and CuCl. Copper salts were found to promote the transformation of the intermediary 4-isoxazolines in
InBr3-catalyzed direct alkynylation of nitrones with terminal alkynes: an efficient synthesis of N-hydroxy-propargyl amines
Ji, Du-Ming,Xu, Ming-Hua
scheme or table, p. 2952 - 2955 (2009/08/07)
An InBr3-catalyzed direct and efficient alkynylation of nitrones with terminal alkynes was developed. The process enables practical synthesis of a wide range of synthetically useful N-hydroxy-propargyl amine derivatives in good yields under mil
Reduction of 2,3-dihydroisoxazoles to β-amino ketones and β-amino alcohols
Aschwanden, Patrick,Kvaerno, Lisbet,Geisser, Roger W.,Kleinbeck, Florian,Carreira, Erick M.
, p. 5741 - 5742 (2007/10/03)
(Chemical Equation Presented) We report the reduction of 2,3-dihydroisoxazoles to β-amino ketones and β-amino alcohols. The latter are obtained in high diastereoselectivity with preference for the syn isomer.
