872714-53-9Relevant academic research and scientific papers
Synthesis and structure-activity relationships of 3-cyano-4(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors
Zhang, Nan,Wu, Biqi,Powell, Dennis,Wissner, Allan,B. Floyd, Middleton,D. Kovacs, Eleonora,Toral-Barza, Lourdes,Kohler, Constance
, p. 2825 - 2828 (2000)
A series of 3-cyano-4-(phenoxyanilino)cyanoquinolines has been prepared as MEK (MAP kinase kinase) inhibitors. The best activity is seen with alkoxy groups at both the 6- and 7-positions. The lead compounds show low nanomolar IC50's against MAP kinase kinase, and have potent inhibitory activity in tumor cells. (C) 2000 Elsevier Science Ltd.
Hetero-aromatic compound and its use in medicine
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Paragraph 1661; 1664-1666, (2019/07/04)
The invention provides a hetero-aromatic compound or a stereisomer, geometric isomer, tautomer, despinner, nitrogen oxide, hydrate, solvate, metabolite, metabolism precursor and pharmaceutically acceptable salt or prodrug thereof, which is used for treating proliferative diseases. The invention also discloses a pharmaceutical composition containing the compound and an application of the compound or pharmaceutical composition thereof in preparation of a medicine for treating proliferative diseases.
ANTIBACTERIAL AGENTS
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Page/Page column 62, (2010/02/15)
Naphthalene, quinoline, quinoxaline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.
