13669-61-9

Usage

Uses

Used in Pharmaceutical Industry:
4-Hydroxy-6-methoxyquinoline-3-carbonitrile is used as a pharmaceutical compound for its antimicrobial properties, making it a potential candidate for the development of new antibiotics to combat resistant bacteria.
4-Hydroxy-6-methoxyquinoline-3-carbonitrile is also used as an anti-inflammatory agent, which can be beneficial in the treatment of various inflammatory conditions and diseases.
Used in Antioxidant Applications:
4-Hydroxy-6-methoxyquinoline-3-carbonitrile is used as an antioxidant in the pharmaceutical industry, where its ability to neutralize free radicals can contribute to the prevention of oxidative stress-related diseases and disorders.
Used in Disease Treatment Research:
4-Hydroxy-6-methoxyquinoline-3-carbonitrile is used as a subject of research for its potential use in the treatment of various diseases and disorders, given its pharmacological properties and the need for novel therapeutic agents.

InChI:InChI=1/C11H8N2O2/c1-15-8-2-3-10-9(4-8)11(14)7(5-12)6-13-10/h2-4,6H,1H3,(H,13,14)

Upstream product

• 75-05-8 acetonitrile 
• 872714-53-9 (E)-methyl 2-(((dimethylamino)methylene)amino)-5-methoxybenzoate 
• 394-31-0 2-amino-5-hydroxybenzoic acid 
• 7507-86-0 2-bromo-5-methoxy-benzaldehyde 
• 50-00-0 formaldehyd 
• 2475-80-1 methyl 2-amino-5-methoxybenzoate 
• 20428-58-4 α-lithioacetonitrile 

Downstream Products

• 13669-62-0 4-chloro-6-methoxy-quinoline-3-carbonitrile 
• 872714-52-8 4-bromo-6-(methyloxy)-3-quinolinecarbonitrile 

Relevant academic research and scientific papers

Hetero-aromatic compound and its use in medicine

The invention provides a hetero-aromatic compound or a stereisomer, geometric isomer, tautomer, despinner, nitrogen oxide, hydrate, solvate, metabolite, metabolism precursor and pharmaceutically acceptable salt or prodrug thereof, which is used for treating proliferative diseases. The invention also discloses a pharmaceutical composition containing the compound and an application of the compound or pharmaceutical composition thereof in preparation of a medicine for treating proliferative diseases.

Copper-Catalyzed Synthesis of Substituted 4-Quinolones using Water as a Benign Reaction Media: Application for the Construction of Oxolinic Acid and BQCA

A copper-catalyzed three-component synthetic method has been developed for the synthesis of substituted 4-quinolone derivatives from substituted 3-(2-halophenyl)-3-oxopropane, aldehydes and aq. NH3 using water as an environmentally benign reaction media. Moreover, the synthetic utility of the obtained products has been successfully applied for the synthesis of available oxolinic acid and BQCA drugs. The key features of this approach include commercially available starting materials, broad scope, and moderate to good reaction yields. Reaction with formaldehyde, and other functionalities such as ?CN, ?NO2, ?SO2Ar, and ?COAr were also successful. In addition, reaction with heterocyclic compounds such as 3-(3-bromothiophen-2-yl)-3-oxopropanenitrile proceeded smoothly to afford tetrahydrothieno[3,2-b]pyridine-6-carbonitrile analogues. The practicality of the designed protocol was confirmed by gram scale synthesis of two derivatives. (Figure presented.).

ANTIVIRAL AGENTS

Compounds are provided having utility for the treatment of viral infections, particularly HCV.

ANTIBACTERIAL AGENTS

Naphthalene, quinoline, quinoxaline and naphthyridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans, are disclosed herein.

Synthesis and structure-activity relationships of 3-cyano-4(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors

A series of 3-cyano-4-(phenoxyanilino)cyanoquinolines has been prepared as MEK (MAP kinase kinase) inhibitors. The best activity is seen with alkoxy groups at both the 6- and 7-positions. The lead compounds show low nanomolar IC50's against MAP kinase kinase, and have potent inhibitory activity in tumor cells. (C) 2000 Elsevier Science Ltd.