872725-59-2

Upstream product

• 93768-83-3 (2,3,4,5-tetramethylcyclopenta-2,4-dien-1-yl)-benzene 
• 126910-37-0 1-phenyl-2,3,4,5-tetramethyl-1,3-cyclopentadiene 
• 64417-14-7 3-phenyl-1,2,4,5-tetramethyl-1,3-cyclopentadiene 
• 7647-14-5 sodium chloride 

Downstream Products

• 872725-60-5 [Rh(C₅Me₄Ph)(pyridine)Me₂] 
• 1351363-42-2 C₂₆H₂₅ClNRh 
• 1351363-57-9 C₂₈H₃₁ClN₄Rh⁽¹⁺⁾*F₆P^(1-) 
• 1351363-68-2 C₂₉H₃₂ClN₃Rh⁽¹⁺⁾*F₆P^(1-) 

Relevant academic research and scientific papers

Synthesis and structural characterization of a photoresponsive organodirhodium complex with active S-S bonds: [(CpPhRh)2(μ-CH2)2(μ-O2SSO2)] (CpPh = η5-C5Me4Ph)

A photoresponsive rhodium dinuclear complex having phenyltetramethylcyclopentadienyl (CpPh = η5-C5Me4Ph) and photosensitive dithionite (μ-O2SSO2) ligands, [(CpPhRh)2(μ-CH2)2(μ-O2SSO2)] (1), has been synthesized. The crystal of complex 1 (monoclinic, C2/m (No. 12), a = 24.805(2) A?, b = 29.111(2) A?, c = 10.8475(11) A?, β = 105.9830(7)°, V = 7530.0(12) A?3, Z = 8) consists of two independent molecules, 1-cis and 1-trans, with different arrangement of the CpPh ligands. The flexibility, volume, and shape of the reaction cavities around the dithionite unit of 1-cis and 1-trans in the crystal are discussed. The crystal structures of the precursors of 1, trans-[(CpPhRh)2(μ-Cl)2Cl2] and trans-[(CpPhRh)2(μ-CH2)2Me2], are also reported.

Ligand-Controlled Reactivity and Cytotoxicity of Cyclometalated Rhodium(III) Complexes

We report the synthesis, characterization and cytotoxicity of six cyclometalated rhodium(III) complexes [CpXRh(C^N)Z]0/+, in which CpX = Cp*, Cpph, or Cpbiph, C^N = benzo[h]quinoline, and Z = chloride or pyridine. Three X-ray crystal structures showing the expected “piano-stool” configurations have been determined. The chlorido complexes hydrolyzed faster in aqueous solution, and reacted preferentially with 9-ethyl guanine or glutathione compared to their pyridine analogues. The 1-biphenyl-2,3,4,5-tetramethylcyclopentadienyl complex [CpbiphRh(benzo-[h]quinoline)Cl] (3a) was the most efficient catalyst in coenzyme reduced nicotinamide adenine dinucleotide (NADH) oxidation to NAD+ and induced an elevated level of reactive oxygen species (ROS) in A549 human lung cancer cells. The pyridine complex [CpbiphRh(benzo[h]quinoline)py]+ (3b) was the most potent against A549 lung and A2780 ovarian cancer cell lines, being 5-fold more active than cisplatin towards A549 cells, and acted as a ROS scavenger. This work highlights a ligand-controlled strategy to modulate the reactivity and cytotoxicity of cyclometalated rhodium anticancer complexes.

Rapid Access to Derivatized, Dimeric, Ring-Substituted Dichloro(cyclopentadienyl)rhodium(III) and Iridium(III) Complexes

The present work describes the design and synthesis of a series of rhodium and iridium dimers [(η5-ring)MCl]2(μ2-Cl)2 (where (η5-ring)MCl = (η5-Me4C5R)Rh(III)Cl or (η

Half-sandwich rhodium(III) transfer hydrogenation catalysts: Reduction of NAD+ and pyruvate, and antiproliferative activity

Organometallic complexes have the potential to behave as catalytic drugs. We investigate here Rh(III) complexes of general formula [(Cpx)Rh(N,N′)(Cl)], where N,N′ is ethylenediamine (en), 2,2′-bipyridine (bpy), 1,10-phenanthroline (phen) or N-(

NOVEL IRIDIUM/RHODIUM ANTI-CANCER COMPOUNDS

The present invention relates to novel iridium and/or rhodium containing complexes for use as a cytotoxic, such as an anti-cancer agent. There is also provided a method of preparing said compounds.

Mechanistic insights into an unprecedented C-C bond activation on a Rh/Ga bimetallic complex: A combined experimental/computational approach

The unusual rearrangement of [RhCp*(GaCp*)(CH3) 2] (1c) to [RhCp*(C5Me4Ga(CH 3)3)] (2) is presented and its mechanism is discussed in detail. 13C MAS NMR spectroscopy revealed that the title reaction proceeds cleanly not only in solution but also in solid state, which supports a unimolecular reaction pathway. On the basis of 1H, 13C, and ROESY NMR spectroscopy as well as isolation and structural elucidation of the hydrolysis product, the compound [RhCp*(endo-η4-C 5Me5GaMe2)] (3a) was identified as a crucial reaction intermediate. DFT calculations on the B3LYP level of theory support this assignment and suggest a concerted C-C bond activation mechanism that topologically takes place at the gallium center. Furthermore, two fluxional processes of the reaction intermediate 3a were studied experimentally as well as by computational methods. First, a mechanism takes place similar to a ring-slipping process that exchanges a GaMe2 group between adjacent ring carbon atoms within the same Cp* ring. This process proceeds at a rate comparable to the NMR time scale and indeed is calculated to be energetically very favorable. Second, a unimolecular exchange process of the GaMe2 group between the two Cp* rings of 3a could be experimentally proven by the introduction of phenyl substituents as a label into the Cp* ligands at both sites, the rhodium as well as the gallium center. A series of experiments including deuteration studies and competition reactions was performed to substantiate the suggested mechanism being in accordance with DFT calculations on possible transition states.