872729-80-1Relevant academic research and scientific papers
New potential renin inhibitors with dipeptide replacements in the molecule
Winiecka, Iwona,Dudkiewicz-Wilczynska, Jadwiga,Roman, Iza,Paruszewski, Ryszard
, p. 367 - 374 (2011/08/04)
A series of eight non-peptidic potential renin inhibitors have been designed and synthesized. All of them contain dipeptide replacement: (3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoic acid (ACHPA) in their molecules. Four among them comprise two additional analogs of dipeptide: (3S,4S)-4-amino-3-hydroxy-5-phenylpentanoic acid (AHPPA) and (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid (statine, Sta). All of the synthesized compounds contain also hydrophobic portions to receive a moderate lipophilicity of the molecules. Inhibitory activity of the compounds was measured in vitro by HPLC determination of Leu-Val-Tyr-Ser released from the N-acetyltetradecapeptide substrate by renin in the presence of the inhibitor. Asp-α(OEt)-(S,S)-ACHPA-εAhx-Iaa (23) shows inhibitory activity (7%) at the concentration of 1.0 × 10-2 M. The other synthesized compounds show no inhibitory activity up to this concentration.
New renin inhibitors containing pseudodipeptidic units in P 3-P2 and P1-P1′ positions
Paruszewski, Ryszard,Jaworski, Pawel,Bodnar, Magdalena,Dudkiewicz-Wilczynska, Jadwiga,Roman, Iza
, p. 1305 - 1309 (2007/10/03)
A series of four non-peptidic renin inhibitors have been designed and synthesized. All of them contain in their molecule (3S,4S)-4-amino-5-cyclohexyl- 3-hydroxypentanoic acid (ACHPA), a hydrophobic portion at the C-terminus and a second dipeptide-like tra
