872973-93-8

Basic information

• Product Name: 1,6-Naphthyridin-2(1H)-one, 7-chloro-1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-
• CAS NO: 872973-93-8
• Molecular Formula: C20H9Cl3F2N2O
• Molecular Weight: 437.66
• Mol File: 872973-93-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,6-Naphthyridin-2(1H)-one, 7-chloro-1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,6-Naphthyridin-2(1H)-one, 7-chloro-1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-(872973-93-8)
• EPA Substance Registry System: 1,6-Naphthyridin-2(1H)-one, 7-chloro-1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-(872973-93-8)

Safety Data

• Hazardous Substances Data: 872973-93-8(Hazardous Substances Data)

Usage

Molecular Structure

The compound has a complex molecular structure with a naphthyridine ring, a chloro substituent at the 7th position, a 2,6-dichlorophenyl group, and a 2,4-difluorophenyl group.

Molecular Weight

The molecular weight of the compound is approximately 411.24 g/mol.

Potential Applications

The compound has potential biological activity and may be used in pharmaceutical research for the development of new drugs.

Further Study

The precise chemical properties and potential applications of the compound would need to be further studied and analyzed.

Solubility

The solubility of the compound in various solvents is not mentioned in the provided material.

Stability

The stability of the compound under different conditions is not mentioned in the provided material.

Reactivity

The reactivity of the compound with other chemicals or under different conditions is not mentioned in the provided material.

Toxicity

The toxicity of the compound is not mentioned in the provided material.

Environmental Impact

The environmental impact of the compound is not mentioned in the provided material.

Upstream product

• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 872973-88-1 1-(2,6-dichlorophenyl)-6-(4-methoxybenzyl)-1,6-naphthyridone-2,5,7-(1H,6H,8H)-trione 
• 872973-83-6 4-[(2,6-dichlorophenyl)amino]-1-(4-methoxybenzyl)pyridine-2,6-(1H,3H)-dione 
• 872973-91-6 1-(2,6-dichlorophenyl)-7-hydroxy-1,6-naphthyridine-2,5-(1H,6H)-dione 
• 37511-45-8 N-2,6-dichlorophenyl-acrylamide 
• 14432-12-3 4-Amino-2-chloropyridine 
• 73583-37-6 2-chloro-4-bromopyridine 
• 444665-44-5 1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-1,6-naphthyridin-2(1H)-one 
• 916203-59-3 5-chloro-1-(2,6-dichlorophenyl)-1,6-naphthyridin-2(1H)-one 
• 916203-52-6 4-bromo-2-chloro-3-iodo-pyridine 
• 913556-82-8 1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-1,6-naphthyridin-2(1H)-one 6-oxide 
• 872973-92-7 5,7-dichloro-1-(2,6-dichlorophenyl)-1,6-naphthyridin-2-(1H)-one 
• 144025-03-6 2,4-difluorophenylboronic acid 

Relevant articles and documents

Synthesis of a naphthyridone p38 MAP kinase inhibitor

Compound 1 is a p38 MAP kinase inhibitor potentially useful for the treatment of rheumatoid arthritis and psoriasis. A novel six-step synthesis suitable for large-scale preparation was developed in support of a drug development program at Merck Research Laboratories. The key steps include a tandem Heck-lactamization, N-oxidation, and a highly chemoselective Grignard addition of 4-(N-tert-butylpiperidinyl)-magnesium chloride to a naphthyridone N-oxide. The N-oxide exerted complete chemoselectivity via chelation in directing the Grignard addition to the α position as opposed to 1,4-addition on the enelactam. The dihydropyridyl adduct was in situ aromatized with isobutylchloroformate followed by heating in pyridine. Syntheses of Grignard precursor, N-tert-butyl-4-chloro-piperidine, were accomplished via transamination with a quaternary ammonium piperidone or via addition of methylmagnesium chloride to an iminium ion. Utilizing this chemistry, multi-kilogram preparation of compound 1 was successfully demonstrated. American Chemical Society.