872988-43-7

Basic information

• Product Name: 1H-Pyrazole-3,4-dicarboxylic acid, 1,5-diphenyl-, 4-ethyl ester
• CAS NO: 872988-43-7
• Molecular Formula: C19H16N2O4
• Molecular Weight: 336.347
• Mol File: 872988-43-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole-3,4-dicarboxylic acid, 1,5-diphenyl-, 4-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-3,4-dicarboxylic acid, 1,5-diphenyl-, 4-ethyl ester(872988-43-7)
• EPA Substance Registry System: 1H-Pyrazole-3,4-dicarboxylic acid, 1,5-diphenyl-, 4-ethyl ester(872988-43-7)

Safety Data

• Hazardous Substances Data: 872988-43-7(Hazardous Substances Data)

Upstream product

• 134567-92-3 ethyl 4,5-dioxo-2-phenyl-4,5-dihydrofuran-3-carboxylate 
• 588-64-7 benzaldehyde phenylhydrazone 
• 471-47-6 oxamic acid 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 100-63-0 phenylhydrazine 
• 100-47-0 benzonitrile 

Downstream Products

• 957470-78-9 3-(chlorocarbonyl)-1,5-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 63515-04-8 2,3-diphenyl-5,6-dihydro-2H-pyrazolo[3,4-d]pyridazine-4,7-dione 
• 53561-07-2 1,5-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 1262234-20-7 1,5-diphenyl-1H-pyrazole-3,4-dicarbonyl dichloride 
• 35280-08-1 1,5-diphenyl-1H-pyrazole-3,4-dicarboxylic acid 

Relevant articles and documents

Expeditious solid-phase synthesis of pyrazoledicarboxylic acid derivatives by functionalization of resin-bound cyanoformate

Esterification of the Wang resin 5 with the monoamide of oxalic acid (oxamic acid, 7) followed by dehydration of the amide function furnishes the resin-bound cyanoformate 9, which can be elaborated by zinc-catalyzed reaction with β-keto esters. The obtained enamino keto diesters 10a-d react with hydrazines affording, after removal from the solid support, fully substituted pyrazoledicarboxylic acids 12a-n. Optimization of the above sequence and the solid-phase synthesis of a small test-library of 1,5-disubstituted pyrazole-3,4-dicarboxylic acid derivatives are described. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.

Synthesis and some reactions of 4-(ethoxycarbonyl)-1,5-diphenyl- 1H-pyrazole-3-carboxylic acid

(Chemical Equation Presented) 1,5-Diphenyl-1H-pyrazole-3,4-dicarboxylic acid-4-ethyl ester 2, obtained from the 4-ethoxycarbonyl-5-phenyl-2,3-furandione 1 and N-benzylidene-N1-phenyl hydrazine, was converted via reactions of its acid chloride 3 with various alcohols or N-nucleophiles into the corresponding ester 5 or amide derivatives 6, respectively. In addition, 2 was decarboxylated to give ethyl 1,5-diphenylpyrazole-4-carboxylate 4. Nitrile 7 derivative of 2 was also obtained by dehydration of 6a in a mixture of SOCl 2 and DMF. While cyclocondensation reaction of 2 with hydrazine hydrate leads to the formation of pyrazolo[3,4-d]pyridazine-4,7-dione 8, the reaction of 3 with anhydrous hydrazine provided a new bis pyrazole derivative 9.