1236303-09-5

Basic information

• Product Name: Methyl 2-iodo-4-(trifluoromethyl)benzoate
• Synonyms: Methyl 2-iodo-4-(trifluoromethyl)benzoate;Methyl 2-iodo-4-(trifluoromethyl)benzoate 97%;Methyl 2-iodo-alpha,alpha,alpha-trifluoro-p-toluate, 3-Iodo-4-(methoxycarbonyl)benzotrifluoride;Methyl2-iodo-4-(trifluoromethyl)benzoate97%;2-Iodo-4-trifluoromethyl-benzoic acid methyl ester;methyl 2-iodo-4-(trifluromethyl)benzoate
• CAS NO: 1236303-09-5
• Molecular Formula: C₉H₆F₃IO₂
• Molecular Weight: 330.0424196
• Mol File: 1236303-09-5.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 2-iodo-4-(trifluoromethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-iodo-4-(trifluoromethyl)benzoate(1236303-09-5)
• EPA Substance Registry System: Methyl 2-iodo-4-(trifluoromethyl)benzoate(1236303-09-5)

Safety Data

• Hazardous Substances Data: 1236303-09-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
Methyl 2-iodo-4-(trifluoromethyl)benzoate is utilized as a reagent in the synthesis of various pharmaceuticals and agrochemicals, leveraging its capacity to promote carbon-carbon bond formation. This property is crucial for the development of new and effective drugs and pesticides.
Used in the Production of Specialized Materials:
In the specialized materials industry, methyl 2-iodo-4-(trifluoromethyl)benzoate is employed in the creation of liquid crystals and polymers. Its unique chemical structure contributes to the specific properties required for these advanced materials, which have applications in various high-tech fields.

Upstream product

• 61500-87-6 methyl 2-Amino-4-(trifluoromethyl)benzoate 
• 402-13-1 2-amino-4-trifluoromethylbenzoic acid 
• 67-56-1 methanol 
• 1261586-48-4 C₈H₃ClF₃IO 
• 54507-44-7 2-iodo-4-(trifluoromethyl)benzoic acid 

Downstream Products

• 873005-49-3 (2-iodo-4-(trifluoromethyl)phenyl)methanol 
• 1369842-42-1 methyl 2-[(diethoxyphosphoryl)difluoromethyl]-4-(trifluoromethyl)benzoate 
• 1236303-10-8 2-cyclohexyl-4-trifluoromethyl-benzoic acid methyl ester 
• 1360789-47-4 methyl 4-trifluoromethyl-2-((E)-4-hydroxybut-1-enyl)benzoate 
• 1360789-88-3 C₁₉H₂₇F₃O₃Si 

Relevant articles and documents

F- Nucleophilic-Addition-Induced [3 + 2] Annulation: Direct Access to CF3-Substituted Indenes

An efficient [3 + 2] annulation of (2,2-difluorovinyl)-2-iodoarenes and internal alkynes was developed for the synthesis of 1-(trifluoromethyl)-1H-indenes. The success of this strategy hinges upon a well-balanced process for the generation of two transient reactive species, specifically trifluoroethylsilver and alkenylpalladium intermediates, in the same molecule, as well as a smooth transmetalation step, which delicately joins together these two different metallic intermediates.

Palladium-catalyzed annulation reactions of methyl o-halobenzoates with azabicyclic alkenes: A general protocol for the construction of benzo[c]phenanthridine derivatives

The annulation reaction of methyl o-halobenzoates with azabicyclic alkenes proceeds efficiently to give the corresponding benzo[c]phenanthridine derivatives in good to excellent yields using a developed base-free methodology based on our preliminary studies. Thirty-seven application examples validate the compatibility of the present strategy with different groups, particularly with the electron-deficient ones, that are difficult to access using other traditional methods. In addition, annulation reactions with non-symmetric azabicyclic alkenes are achieved in high regioselectivity.

PIPERIDINE DERIVATIVES

The present invention relates to a compound of formula I wherein R1, R2, and Ar are as defined herein or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical iso