873192-83-7Relevant articles and documents
3-Arylpiperazinylethyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives as novel, high-affinity and selective α1- adrenoceptor ligands
Pittala, Valeria,Romeo, Giuseppe,Salerno, Loredana,Siracusa, Maria Angela,Modica, Maria,Materia, Luisa,Mereghetti, Ilario,Cagnotto, Alfredo,Mennini, Tiziana,Marucci, Gabriella,Angeli, Piero,Russo, Filippo
, p. 150 - 153 (2006)
The discovery of a new series of selective and high-affinity α1-adrenoceptor (α1-AR) ligands, characterized by a 1H-pyrrolo[2,3-d]-pyrimidine-2,4(3H,7H)-dione system, is described in this paper. Some synthesized compounds, including 20, 22, and 30, displayed affinity in the nanomolar range for α1-ARs and substantial selectivity with respect to 5-HT1A and dopaminergic D1 and D 2 receptors. Functional assays, performed on selected derivatives, showed antagonistic properties.