Bioorganic and Medicinal Chemistry Letters p. 150 - 153 (2006)
Update date:2022-07-29
Topics:
Pittala, Valeria
Romeo, Giuseppe
Salerno, Loredana
Siracusa, Maria Angela
Modica, Maria
Materia, Luisa
Mereghetti, Ilario
Cagnotto, Alfredo
Mennini, Tiziana
Marucci, Gabriella
Angeli, Piero
Russo, Filippo
The discovery of a new series of selective and high-affinity α1-adrenoceptor (α1-AR) ligands, characterized by a 1H-pyrrolo[2,3-d]-pyrimidine-2,4(3H,7H)-dione system, is described in this paper. Some synthesized compounds, including 20, 22, and 30, displayed affinity in the nanomolar range for α1-ARs and substantial selectivity with respect to 5-HT1A and dopaminergic D1 and D 2 receptors. Functional assays, performed on selected derivatives, showed antagonistic properties.
View Morewebsite:http://www.antaibio.com
Contact:86-21-60939051,60939771
Address:Room 2108, Building 2,No. 489 Zhengli Road,200433
Jinhua Haoyuan Chemical CO., LTD(expird)
Contact:86-579-82465583
Address:Jinhua,Zhejiang
Huangshan Honghui Pharm Technology Co., Ltd.(expird)
website:http://www.honghuichem.com
Contact:18855958372
Address:Qingshan Wan No.1,Nanyuan Kou,SheXian Huangshan City,Anhui Province
Hangzhou Ocean Chemical Co., Ltd.
website:http://www.hzoceanchem.com
Contact:+86-571-88025872, 28272092, 28272096
Address:Room 623 ,Building No 1 , COFCO Radius Commercial Center Xiwen Road, Xiacheng District, Hangzhou, Zhejiang Province, China
Contact:+49-9398-993127
Address:Untertorstr. 27
Doi:10.1002/chem.200500384
(2005)Doi:10.1016/S0040-4039(02)02179-2
(2002)Doi:10.1021/om050902e
(2006)Doi:10.1039/d0pp00114g
(2020)Doi:10.1016/j.bmcl.2007.01.076
(2007)Doi:10.1016/j.bmcl.2005.09.086
(2006)