873200-44-3Relevant academic research and scientific papers
Polyhydroxylated GdDTPA-derivatives as high relaxivity magnetic resonance imaging contrast agents
Tei, Lorenzo,Barge, Alessandro,Galli, Matteo,Pinalli, Roberta,Lattuada, Luciano,Gianolio, Eliana,Aime, Silvio
, p. 74734 - 74743 (2015/09/22)
The search for new MRI agents endowed with high relaxivity at the magnetic field strength of clinical scanners (1.5-3 T) is still receiving great attention from researchers involved in the development of new probes. Such Gd(iii) complexes should combine a
Highly efficient asymmetric mannich reaction of dialkyl α-diazomethylphosphonates with N -carbamoyl imines catalyzed by chiral bronsted acids
Zhang, Hui,Wen, Xiaojing,Gan, Lihua,Peng, Yungui
supporting information; experimental part, p. 2126 - 2129 (2012/07/17)
An efficient method involving the first use of chiral phosphoric acids as catalysts in the asymmetric Mannich reaction of dialkyl diazomethylphosphonates and N-carbamoyl imines is developed. With only 0.1 mol % catalyst 1f, the reaction proceeded smoothly and produced the corresponding β-amino-α- diazophosphonate with up to 97% yield and >99% ee.
CONTRAST AGENTS ENDOWED WITH HIGH RELAXIVITY
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Page/Page column 38-39, (2008/06/13)
The present invention relates to a novel class of paramagnetic ion-based contrast agents of formula (I), wherein a chelating backbone moiety is highly functionalized by the presence of one or more polyhdroxylated chain, that show a pharmacokinetic profile analogous to that of the commonly used T1-general extravascular agents (NSA) but are further characterized by a higher relaxivity.
