873200-46-5Relevant academic research and scientific papers
Polyhydroxylated GdDTPA-derivatives as high relaxivity magnetic resonance imaging contrast agents
Tei, Lorenzo,Barge, Alessandro,Galli, Matteo,Pinalli, Roberta,Lattuada, Luciano,Gianolio, Eliana,Aime, Silvio
, p. 74734 - 74743 (2015)
The search for new MRI agents endowed with high relaxivity at the magnetic field strength of clinical scanners (1.5-3 T) is still receiving great attention from researchers involved in the development of new probes. Such Gd(iii) complexes should combine a
The synthesis of an EDTA-like chelating peptidomimetic building block suitable for solid-phase peptide synthesis
Spengler, Jan,Barker, Michael,Schelhorn, Constanze,García, Jesús,Macias, Maria J.,Albericio, Fernando
, p. 2634 - 2636 (2017)
A novo trifunctional EDTA-like peptidomimetic amino acid is described. This unique building block, which is prepared in a straightforward manner from commercialized starting materials, contains three moieties: a hexadentate chelating unit similar to that
CONTRAST AGENTS ENDOWED WITH HIGH RELAXIVITY
-
Page/Page column 39-40, (2008/06/13)
The present invention relates to a novel class of paramagnetic ion-based contrast agents of formula (I), wherein a chelating backbone moiety is highly functionalized by the presence of one or more polyhdroxylated chain, that show a pharmacokinetic profile analogous to that of the commonly used T1-general extravascular agents (NSA) but are further characterized by a higher relaxivity.
