873312-93-7

Upstream product

• 36640-56-9 4-hydroxymethyl-3-(4-methoxyphenyl)-1H-1-phenylpyrazole 
• 59-88-1 phenylhydrazine hydrochloride 
• 36640-42-3 3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole-4-carboxaldehyde 
• 873312-85-7 4-(chlorophenyl)-3-(4-methoxyphenyl)-1-phenyl-1H-pyrazole 

Downstream Products

• 873313-01-0 C-[3-(4-methoxyphenyl)-1-phenyl-1H-pyrazol-4-yl]methylamine 

Relevant academic research and scientific papers

Synthesis, pharmacological activities and molecular docking studies of pyrazolyltriazoles as anti-bacterial and anti-inflammatory agents

A series of novel pyrazolyl alcohols (5a-h), pyrazolyl azides (6a-h), and pyrazolyltriazoles (8a-h, 10a-p and 12a-l) were prepared and evaluated for their bioactivity (anti-bacterial and anti-inflammatory) profile. The compound 5c displayed the potent anti-bacterial activity against Micrococcus luteus (MIC 3.9 and MBC 7.81 μg/mL). In vitro anti-inflammatory activity data denoted that compound 8b is effective among the tested compounds against IL-6 (IC50 6.23 μM). Docking analysis of compounds 5f, 8a-b, 8e-f and 8h displayed high binding energies for the compounds 8a-b and 8h towards TNF-α dimer (2AZ5 protein) and IL-6 (1ALU protein). In vivo anti-inflammatory activity of compounds 8b and 8h with respect to LPS induced mice model indicated that compound 8h showed significant reduction in TNF-α.

4-Functionally-substituted 3-heterylpyrazoles: XV. 3-Aryl(heteryl)-1- phenyl-4-pyrazolylmethylamines and heterocumulenes obtained therefrom

By reduction of 3-aryl(heteryl)-1-phenyl-4-azidomethyl-pyrazoles in the presence of Raney nickel or by hydrazinolysis of N-[3-aryl(heteryl)-1-phenyl-4- pyrazolylmethyl]phthalimides 4-pyrazolylmethylamines were obtained that in reaction with bis(trichloromethyl) carbonate afforded 3-aryl-(heteryl)-1-phenyl- 4-pyrazolylmethyl isocyanates, and with carbon disulfide furnished 3-aryl-(heteryl)-1-phenyl-4-pyrazolylmethyl isothiocyanates. 2005 Pleiades Publishing, Inc.