87349-75-5

Upstream product

• 75-05-8 acetonitrile 
• 608-31-1 2,6-Dichloroaniline 

Downstream Products

• 87356-73-8 3-(2,6-dichlorophenyl)-2-methyl-6-phenyl-4(3H)-pyrimidinone 
• 1033575-54-0 1-(2,6-dichlorophenyl)-2-(4'-methanesulfonyl-biphenyl-4-yloxymethyl)-4-trifluoromethyl-1H-imidazole 
• 1033586-37-6 2-(4-bromophenoxymethyl)-1-(2,6-dichlorophenyl)-4-trifluoromethyl-1H-imidazole 
• 1033586-36-5 2-bromomethyl-1-(2,6-dichlorophenyl)-4-trifluoromethyl-1H-imidazole 
• 1033586-34-3 1-(2,6-dichlorophenyl)-2-methyl-4-trifluoromethyl-1H-imidazole 
• 87356-59-0 3-(2,6-Dichloro-phenyl)-2-methyl-3H-pyrimidin-4-one 

Relevant academic research and scientific papers

LXR AND FXR MODULATORS

Compounds of the invention are disclosed, such as compounds of formulae LX - LXIV, and pharmaceutically acceptable salts, isomers, or prodrugs thereof, which are useful as modulators of the activity of liver X receptors (LXR) and Farnesoid X receptors (FXR), where R00, R200, R400, R500, J11, J21, G1, G21, and Q are defined herein. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.

Synthesis and Biological Evaluation of 6-Substituted 3-Aryl-2-methyl-4(3H)-pyrimidones

6-Substituted 3-aryl-2-methyl-4(3H)-pyrimidones (III) have been prepared by the reaction of N-arylacetamidines (II) with various diplorophiles like ethyl propiolate, ethyl tetrolate and ethyl phenylpropiolate.The structure of the products has been confirm