873547-39-8Relevant academic research and scientific papers
Discovery of Novel Small-Molecule Inhibitors of NF-κB Signaling with Antiinflammatory and Anticancer Properties
Zhang, Lei,Shi, Lei,Soars, Shafer Myers,Kamps, Joshua,Yin, Hang
, p. 5881 - 5899 (2018)
Excessive NF-κB activation contributes to the pathogenesis of numerous diseases. Small-molecule inhibitors of NF-κB signaling have significant therapeutic potential especially in treating inflammatory diseases and cancers. In this study, we performed a ce
Oxadiazole derivative and application thereof
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, (2019/03/24)
The invention provides an oxadiazole derivative and application thereof. The oxadiazole derivative provided by the invention uses oxadiazole and pyridine as electron acceptors and uses carbazole as anelectron donor to form molecules with different steric hindrances and different conjugated degrees by different connection modes. The molecules have higher triplet state energy level, have both charge and hole transport functions, and can be used as blue or green main body type materials in the field of organic electroluminescence. When the material as a main body is applied to a blue light organic device using FIrpic as an object, a light-emitting device with an external quantum efficiency being 14.6 to 20.8 percent can be obtained. When the material as the main body is applied into a greenorganic light-emitting device using Ir(ppy)3 as the object, a light-emitting device with the external quantum efficiency being 10.6 to 21.8 percent can be obtained.
Syntheses, crystal structures, and spectral characterization of three new asymmetrical substituted triaryltriazoles
Zhao, Jian,Shen, Guo-Ping,Shen, Xuan,Zhu, Dun-Ru,Zhang, Yu
, p. 1114 - 1119,6 (2020/09/16)
Triaryltriazoles are of interest in iron(II) complexes designed to study spin-crossover properties. In this study, three new asymmetrical substituted triaryltriazoles, 3-(p-R-phenyl)-4-(p-chlorophenyl)-5-(2-pyridyl)-1,2,4- triazoles (R = OCH3, 5a; Cl, 5b; Br, 5c), were successfully synthesized from 2-picolinic acid by a three-step reaction through an intermediate N-(p-R-phenylcarbonyl)-N'-(2-pyridylcarbonyl)hydrazine (4a-4c). Yield of 5a-5c is in the range from 74 to 87%. The compounds 5a-5c were characterized by UV, FTIR, 1H-NMR, electrospray ionization mass spectrum spectra, and elemental analysis. Additionally, the absolute configurations of 5a-5c were determined by single crystal X-ray crystallography.
