873548-67-5Relevant academic research and scientific papers
Preparation of Polyfunctional Organozinc Halides by an InX3- and LiCl-Catalyzed Zinc Insertion to Aryl and Heteroaryl Iodides and Bromides
Benischke, Andreas D.,Le Corre, Grégoire,Knochel, Paul
supporting information, p. 778 - 782 (2017/02/05)
A catalytic system consisting of InCl3(3 mol %) and LiCl (30 mol %) allows a convenient preparation of polyfunctional arylzinc halides via the insertion of zinc powder to various aryl iodides in THF at 50 °C in up to 95 % yield. The use of a THF/DMPU (1:1) mixture shortens the reaction rates and allows the preparation of keto-substituted arylzinc reagents. In the presence of In(acac)3(3 mol %) and LiCl (150 mol %), the zinc insertion to various aryl and heteroaryl bromides proceeds smoothly (50 °C, 2–18 h). Alkyl bromides are also converted to the corresponding zinc reagents in the presence of In(acac)3(10 mol %) and LiCl (150 mol %) in 70–80 % yield.
A convenient access to thienyl-substituted phthalazines
Raposo, M. Manuela M.,Sampaio, Ana M. B. A.,Kirsch
, p. 1245 - 1251 (2007/10/03)
A synthesis of 1-alkoxy- and 1-amino- substituted 4-(2-thienyl)- phthalazines is described from halo-derivatives of 4-(2-thienyl)-1-(2H)- phthalazinone 3.
