873556-45-7

Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl 9-((3aR,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylcarbamate is used as a potential pharmaceutical agent for [application reason]. Its complex structure and functional groups may contribute to its biological activity and therapeutic potential, making it a candidate for further research and development in the pharmaceutical field.
Used in Chemical Research:
In the field of chemical research, tert-butyl 9-((3aR,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylcarbamate serves as a subject of study for understanding its synthesis, properties, and potential applications. Its unique structure and functional groups provide opportunities for exploring new chemical reactions and mechanisms, contributing to the advancement of organic chemistry.

Upstream product

• 58-61-7 adenosine 
• 139301-93-2 9-((3aR,4R,6R,6aR)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-amine 
• 362-75-4 2',3'-isopropylidene adenosine 
• 913823-87-7 tert-butyl (9-((3aR,4R,6R,6aR)-6-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)carbamate 
• 686301-05-3 tert-butyl (9-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)carbamate 
• 34245-48-2 5'-azido-5'-deoxy-2',3'-O-isopropylidene adenosine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 873556-44-6 tert-butyl (9-((3aR,4R,6R,6aR)-6-(azidomethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)carbamate 

Downstream Products

• 939794-46-4 (E)-5'-amino-N₆-tert-butoxycarbonyl-5'-deoxy-5'-N-{[3-(2-methoxymethoxy)phenyl]prop-2-ene-1-oyl}-2',3'-O-isopropylideneadenosine 
• 939794-38-4 5'-amino-5'-N-{[(2-benzyloxybenzoyl)amino]carbonyl}-N₆-t-butoxycarbonyl-5'-deoxyadenosine 
• 939794-50-0 5-amino-N₆-tert-butoxycarbonyl-5'-deoxy-5'-N-{[3-(2-methoxymethoxy)phenyl]prop-2-yn-1-oyl}-2',3'-O-isopropylideneadenosine 
• 1094677-96-9 6-N-t-butoxycarbonyl-2',3'-O-isopropylidene-5'-N-(N-[benzyloxycarbonyl]sulfamoyl)aminodeoxyadenosine 
• 1094678-23-5 (E)-6-N-t-butoxycarbonyl-2',3'-O-isopropylidene-5'-N-(5''-[2'''-(methoxycarbonyl)phenyl]-5''-oxopent-1''-ene-1''-sulfonyl)aminodeoxyadenosine 
• 1094678-28-0 (E)-6-N-t-butoxycarbonyl-2',3'-O-isopropylidene-5'-N-(5''-[2'''-(methoxycarbonyl)phenyl]hexa-1'',5''-diene-1''-sulfonyl)aminodeoxyadenosine 
• 939794-41-9 (E)-5'-deoxy-5'-N-({2-[2-(methoxymethoxy)phenyl]ethenyl}sulfonyl)amino-2',3'-O-isopropylideneadenosine 
• 939793-76-7 (E)-5'-deoxy-5'-N-({[2-(2-hydroxyphenyl)ethenyl]sulfonyl}amino)adenosine 

Relevant academic research and scientific papers

NOVEL HISTONE METHYLTRANSFERASE INHIBITORS

The present invention relates to novel compounds of formula (I) as defined herein. The compounds are inhibitors of histone methyltransferases of the seven-beta-strand family, in particular of KMT9.

Antibacterial Agents

The invention provides compounds of formula (I) and salts thereof: R1-L-R2—B wherein R1, L, R2, and B have any of the values defined herein, as well as compositions comprising such compounds, and therapeutic methods comprising the administration of such compounds or salts. The compounds block siderophore production in bacteria and are useful as antibacterial agents.

Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis

Menaquinone (vitamin K2) is an essential component of the electron transfer chain in many pathogens, including Mycobacterium tuberculosis and Staphylococcus aureus, and menaquinone biosynthesis is a potential target for antibiotic drug discovery. We report herein a series of mechanism-based inhibitors of MenE, an acyl-CoA synthetase that catalyzes adenylation and thioesterification of o-succinylbenzoic acid (OSB) during menaquinone biosynthesis. The most potent compound inhibits MenE with an IC50 value of 5.7 μM.

A mechanism-based aryl carrier protein/thiolation domain affinity probe

The design, synthesis, and biochemical characterization of a mechanism-based aryl carrier protein (ArCP) affinity probe that selectively modifies the terminal thiol of the aryl carrier protein phosphopantetheine (Ppant) prosthetic group is described. Labe

5′-O-[(N-acyl)sulfamoyl]adenosines as antitubercular agents that inhibit MbtA: An adenylation enzyme required for siderophore biosynthesis of the mycobactins

A study of the structure - activity relationships of 5′-O-[N- (salicyl)sulfamoyl]adenosine (6), a potent inhibitor of the bifunctional enzyme salicyl-AMP ligase (MbtA, encoded by the gene Rv2384) in Mycobacterium tuberculosis, is described, targeting the salicyl moiety. A systematic series of analogues was prepared exploring the importance of substitution at the C-2 position revealing that a hydroxy group is required for optimal activity. Examination of a series of substituted salicyl derivatives indicated that substitution at C-4 was tolerated. Consequently, a series of analogues at this position provided 4-fluoro derivative, which displayed an impressive MIC 99 of 0.098 μM against whole-cell M. tuberculosis under iron-limiting conditions. Examination of other heterocyclic, cycloalkyl, alkyl, and aminoacyl replacements of the salicyl moiety demonstrated that these nonconserative modifications were poorly tolerated, a result consistent with the fairly strict substrate specificities of related non-ribosomal peptide synthetase adenylation enzymes.

Rationally-designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis

A rationally designed nucleoside inhibitor of Mycobacterium tuberculosis growth (MIC99 = 0.19 μM) that disrupts siderophore biosynthesis was identified. The activity is due to inhibition of the adenylate-forming enzyme MbtA which is involved in