87356-66-9Relevant academic research and scientific papers
Iron-Catalyzed Carbamoylation of Enamides with Formamides as a Direct Approach to N-Acyl Enamine Amides
Shen, Zhen-Yao,Cheng, Jun-Kee,Wang, Cong,Yuan, Chao,Loh, Teck-Peng,Hu, Xu-Hong
, p. 8128 - 8135 (2019)
The robustness of iron catalysis enabling the oxidative coupling reactions of enamides with formamides is described. Routing from readily accessible feedstocks, the efficient approach is implemented to furnish a broad array of value-added N-acyl enamine a
The ruthenium-catalyzed C-H functionalization of enamides with isocyanates: Easy entry to pyrimidin-4-ones
Shi, Pengfei,Li, Song,Hu, Lu-Min,Wang, Cong,Loh, Teck-Peng,Hu, Xu-Hong
, p. 11115 - 11118 (2019/09/20)
Ruthenium-catalyzed heteroannulation between enamides and isocyanates has been realized as a complementary approach to conventional strategies for the synthesis of pyrimidin-4-ones. High step-A nd atom-economy was achieved for the rapid construction of such privileged scaffolds, which are found in a multitude of pharmaceutical compounds. The generality and practicability of this transformation were reflected by the broad scope of substrates with diverse functional groups, large-scale synthesis, and late-stage diversification.
Expedient Synthesis of N-acyl anthranilamides and β-enamine amides by the Rh(III)-catalyzed amidation of aryl and vinyl C-H bonds with isocyanates
Hesp, Kevin D.,Bergman, Robert G.,Ellman, Jonathan A.
, p. 11430 - 11433 (2011/10/02)
A Rh(III)-catalyzed protocol for the amidation of anilide and enamide C-H bonds with isocyanates has been developed. This method provides direct and efficient syntheses of N-acyl anthranilamides, enamine amides, and pyrimidin-4-one heterocycles.
Synthesis and Biological Evaluation of 6-Substituted 3-Aryl-2-methyl-4(3H)-pyrimidones
Gupta, K. A.,Saxena, Anil K.,Jain, Padam C.,Srimal, R. C.,Kar, K.,Anand, Nitya
, p. 384 - 387 (2007/10/02)
6-Substituted 3-aryl-2-methyl-4(3H)-pyrimidones (III) have been prepared by the reaction of N-arylacetamidines (II) with various diplorophiles like ethyl propiolate, ethyl tetrolate and ethyl phenylpropiolate.The structure of the products has been confirm
