873840-99-4

Upstream product

• 873840-90-5 (3R,7aR)-3-(trichloromethyl)-7a-vinyltetrahydropyrrolo[1,2-c]oxazol-1(3H)-one 
• 873840-92-7 (R)-1-tert-butyl 2-methyl 2-vinylpyrrolidine-1,2-dicarboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 147-85-3 L-proline 
• 118916-60-2 (2R,5S)-2-trichloromethyl-1-aza-3-oxabicyclo[3.3.0]octan-4-one 
• 873840-88-1 (2R,3R)-4-oxo-2-(trichloromethyl)-1-aza-3-oxabicyclo[3.3.0]octane-5-carbaldehyde 
• 873840-86-9 (R)-1-(tert-butoxycarbonyl)-2-vinylpyrrolidine-2-carboxylic acid 

Downstream Products

• 873841-01-1 (2S,2'R)-N-[N-(tert-butoxycarbonyl)-2-(hydroxymethyl)prolin-1-yl]-O-(2,6-dichlorobenzyl)tyrosyne methyl ester 
• 873841-02-2 (2S,4'R)3-[4-(2,6-dichlorobenzyloxy)phenyl]-2-[5-(tert-butoxycarbonyl)-1-oxo-2,5-diazaspiro[3.4]oct-2-yl]propionic acid methyl ester 

Relevant academic research and scientific papers

Chirospecific synthesis of spirocyclic β-lactams and their characterization as potent type II β-turn inducing peptide mimetics

Starting from natural proline, a practical chirospecific synthesis of spirocyclic β-lactmans of type 2 is described when a methylene moiety showing minimal steric demand is employed as a constraint element for adjusting the dihedral angle Ψ(i + 1). Employ