873841-01-1Relevant articles and documents
Chirospecific synthesis of spirocyclic β-lactams and their characterization as potent type II β-turn inducing peptide mimetics
Bittermann, Holger,Gmeiner, Peter
, p. 97 - 102 (2006)
Starting from natural proline, a practical chirospecific synthesis of spirocyclic β-lactmans of type 2 is described when a methylene moiety showing minimal steric demand is employed as a constraint element for adjusting the dihedral angle Ψ(i + 1). Employ