873913-87-2 Usage
Uses
Used in Pharmaceutical Industry:
6-Chloro-2,3-diphenylimidazo[1,2-b]pyridazine is used as a PARP inhibitor for its potential therapeutic effects in cancer treatment. 6-Chloro-2,3-diphenylimidazo[1,2-b]pyridazine's ability to inhibit PARP enzymes can lead to the accumulation of DNA damage in cancer cells, making them more susceptible to the effects of DNA-damaging agents such as chemotherapy and radiation therapy. This mechanism of action has shown promise in enhancing the efficacy of cancer treatments, especially in cases where tumors have developed resistance to conventional therapies.
Used in Cancer Therapy Research:
In the field of cancer therapy research, 6-Chloro-2,3-diphenylimidazo[1,2-b]pyridazine is utilized as a subject of investigation for its potential to improve patient outcomes. Ongoing studies are exploring the compound's synergistic effects when combined with various DNA-damaging agents, aiming to identify optimal treatment strategies and combinations that can maximize the therapeutic benefits while minimizing side effects.
Used in Drug Development:
6-Chloro-2,3-diphenylimidazo[1,2-b]pyridazine is also used in drug development as a lead compound for the creation of novel PARP inhibitors. The exploration of CDP and its derivatives is crucial for the advancement of targeted cancer therapies, as it can provide insights into the structure-activity relationships of PARP inhibitors and facilitate the design of more potent and selective agents.
Overall, the applications of 6-Chloro-2,3-diphenylimidazo[1,2-b]pyridazine are primarily centered around its role as a PARP inhibitor, with implications for cancer treatment, research, and drug development. Its unique chemical structure and biological activity make it a valuable asset in the ongoing quest to improve cancer therapies and patient outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 873913-87-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,3,9,1 and 3 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 873913-87:
(8*8)+(7*7)+(6*3)+(5*9)+(4*1)+(3*3)+(2*8)+(1*7)=212
212 % 10 = 2
So 873913-87-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H12ClN3/c19-15-11-12-16-20-17(13-7-3-1-4-8-13)18(22(16)21-15)14-9-5-2-6-10-14/h1-12H
873913-87-2Relevant academic research and scientific papers
Efficient and regioselective functionalization of imidazo[1,2-b]pyridazines via palladium-catalyzed cross-coupling reaction and SNAr
El Akkaoui,Koubachi,El Kazzouli,Berteina-Raboin,Mouaddib,Guillaumet
, p. 2472 - 2475 (2008/09/20)
The synthesis of 3,6-disubstituted-2-phenylimidazo[1,2-b]pyridazine derivatives by palladium cross-coupling and SNAr reactions is described. Sonogashira and Stille cross-coupling reactions were investigated to introduce alkynyl, alkenyl, and ar
FUSED HETEROCYCLES AS LCK INHIBITORS
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Page/Page column 32, (2010/11/25)
There is provided fused heterocycles of imidazopyridazine or pyrazolopyrimidine derivative represented by the formula (I), which have excellent Lck inhibitory activity and are useful for a medicament particularly an immunosuppressive agent. [wherein one of Y and Z is C atom, and the other is N atom; -X-10 is -N (R1) - or the like, -R1 is hydrogen or the like, -A- is bond or the like, is cycloalkyl, aryl or the like, -E- is bond or the like, -R3 is aryl, aromatic heterocycle or the like, -R4, -R5 and -R6 are the same or different, each being hydrogen or the like.]
New calcineurin inhibiting 3-dimethylaminopropyl substituted diarylheterocycles by sonogashira reactions and catalytic hydrogenation
Yin, Lunxiang,Erdmann, Frank,Liebscher, Juergen
, p. 1369 - 1379 (2007/10/03)
A series of calcineurin inhibiting compounds 1 consisting of a central aromatic N-heterocycle, two aryl substituents and a 3-dimethylaminopropyl chain was synthesized by introduction of the side chain. A corresponding haloheterocycle 3 was transformed int
