6-Chloro-2,3-diphenylimidazo[1,2-b]pyridazine

Base Information

• Chemical Name: 6-Chloro-2,3-diphenylimidazo[1,2-b]pyridazine
• CAS No.: 873913-87-2
• Molecular Formula: C18H12ClN3
• Molecular Weight: 305.766
• DSSTox Substance ID: DTXSID20467777
• Nikkaji Number: J2.570.846F
• Wikidata: Q72449725
• Mol file: 873913-87-2.mol

Synonyms:6-Chloro-2,3-diphenylimidazo[1,2-b]pyridazine;873913-87-2;SCHEMBL3037601;DTXSID20467777;WOPARXSWYJDAQV-UHFFFAOYSA-N;FT-0702076

Chemical Property of 6-Chloro-2,3-diphenylimidazo[1,2-b]pyridazine

Chemical Property:

• Refractive Index: 1.681
• PSA: 30.19000
• Density: 1.286 g/cm³
• LogP: 4.71670
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 305.0719751
• Heavy Atom Count: 22
• Complexity: 365

Purity/Quality:

98%min ^*data from raw suppliers

6-Chloro-2,3-diphenylimidazo[1,2-b]pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(N3C(=N2)C=CC(=N3)Cl)C4=CC=CC=C4

Technology Process of 6-Chloro-2,3-diphenylimidazo[1,2-b]pyridazine

There total 2 articles about 6-Chloro-2,3-diphenylimidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-chloro-3-iodo-2-phenylimidazo[1,2-b]pyridazine (1023697-90-6) + tributylphenylstannane (960-16-7) → 6-chloro-2,3-diphenyl-imidazo[1,2-b]pyridazine (873913-87-2)

Guidance literature:

With triphenyl-arsane; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In 1,4-dioxane; at 50 ℃; for 12h;

DOI:10.1016/j.tetlet.2008.02.008

Reference yield: 77.0%

6-chloro-pyridazin-3-ylamine (5469-69-2) + desyl bromide (1484-50-0) → 6-chloro-2,3-diphenyl-imidazo[1,2-b]pyridazine (873913-87-2)

Guidance literature:

With sodium hydrogencarbonate; In isopropyl alcohol; for 12h; Heating;

DOI:10.1002/jhet.5570420717

Reference yield: 92.0%

6-chloro-2,3-diphenyl-imidazo[1,2-b]pyridazine (873913-87-2) + methanol (67-56-1) → C19H15N3O (1023698-05-6)

Guidance literature:

With sodium methylate; for 12h; Heating;

DOI:10.1016/j.tetlet.2008.02.008

upstream raw materials:

6-chloro-pyridazin-3-ylamine

desyl bromide

6-chloro-3-iodo-2-phenylimidazo[1,2-b]pyridazine

tributylphenylstannane

Downstream raw materials:

C₁₉H₁₅N₃O

C₂₆H₂₂N₄O₂