873960-38-4Relevant academic research and scientific papers
Silver-catalyzed Meerwein arylation: Intermolecular and intramolecular fluoroarylation of styrenes
Guo, Rui,Yang, Haodong,Tang, Pingping
supporting information, p. 8829 - 8832 (2015/05/20)
The first example of silver-catalyzed intermolecular and intramolecular Meerwein fluoroarylation of styrenes with aryl diazonium salts has been developed. This reaction is operationally simple, scalable and proceeds under mild conditions. Furthermore, fluorinated dihydrobenzofurans and indolines were easily accessed using this method. This journal is
Kinesin spindle protein (KSP) inhibitors. Part 7: Design and synthesis of 3,3-disubstituted dihydropyrazolobenzoxazines as potent inhibitors of the mitotic kinesin KSP
Garbaccio, Robert M.,Tasber, Edward S.,Neilson, Lou Anne,Coleman, Paul J.,Fraley, Mark E.,Olson, Christy,Bergman, Jeff,Torrent, Maricel,Buser, Carolyn A.,Rickert, Keith,Walsh, Eileen S.,Hamilton, Kelly,Lobell, Robert B.,Tao, Weikang,South, Vicki J.,Diehl, Ronald E.,Davide, Joseph P.,Yan, Youwei,Kuo, Lawrence C.,Li, Chunze,Prueksaritanont, Thomayant,Fernandez-Metzler, Carmen,Mahan, Elizabeth A.,Slaughter, Donald E.,Salata, Joseph J.,Kohl, Nancy E.,Huber, Hans E.,Hartman, George D.
, p. 5671 - 5676 (2008/04/07)
Observations from two structurally related series of KSP inhibitors led to the proposal and discovery of dihydropyrazolobenzoxazines that possess ideal properties for cancer drug development. The synthesis and characterization of this class of inhibitors
MITOTIC KINESIN INHIBITORS
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Page/Page column 60, (2008/06/13)
The present invention relates to tricyclic pyrazoles according to Formula (I) that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also rel
MITOTIC KINESIN INHIBITORS
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Page/Page column 37-38, (2010/10/20)
The present invention relates to tricyclic pyrazoles according to Formula (III) that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also r
