874-33-9

Basic information

• Product Name: N-METHYL-N-(2-METHYLBENZYL)AMINE
• Synonyms: 2-Methyl-N-methylbenzylamine;(2-Methylbenzyl)methylamine;methyl(2-methylbenzyl)amine;N-methyl-1-(2-methylphenyl)methanamine;N-METHYL-N-(2-METHYL;N-methyl-1-(2-methylphenyl)methanamine(SALTDATA: HCl);N-methyl-1-(2-methylphenyl)methanamine 1HCl;N-Methyl-1-(2-Methylphenyl)MethanaMin hydrochloride
• CAS NO: 874-33-9
• Molecular Formula: C₉H₁₃N
• Molecular Weight: 135.21
• Mol File: 874-33-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 129 °C
• Boiling Point: 196.5°C at 760 mmHg
• Flash Point: 78.9°C
• Appearance: /
• Density: 0.917±0.06 g/cm3(Predicted)
• Vapor Pressure: 0.398mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.76±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: N-METHYL-N-(2-METHYLBENZYL)AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHYL-N-(2-METHYLBENZYL)AMINE(874-33-9)
• EPA Substance Registry System: N-METHYL-N-(2-METHYLBENZYL)AMINE(874-33-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 874-33-9(Hazardous Substances Data)

Usage

Uses

(R)-N-methyl-2-methylbenzylamine is resistant to displacement by the aqueous extractants.

InChI:InChI=1/C9H13N/c1-8-5-3-4-6-9(8)7-10-2/h3-6,10H,7H2,1-2H3/p+1

Upstream product

• 89-92-9 2-methylbenzyl bromide 
• 74-89-5 methylamine 
• 2170-09-4 N,2-dimethylbenzamide 
• 593-51-1 methylamine hydrochloride 
• 529-20-4 2-methylphenyl aldehyde 
• 18100-53-3 N-[(2-methylphenyl)methylene]methanamine 
• 118-90-1 ortho-methylbenzoic acid 
• 67-56-1 methanol 
• 126799-83-5 2-methylbenzylazide 
• 89-93-0 ortho-methylbenzylamine 

Downstream Products

• 1262999-57-4 2-(methyl(2-methylbenzyl)amino)benzaldehyde 
• 529-20-4 2-methylphenyl aldehyde 
• 1415240-27-5 C₁₈H₂₁NO 
• 1415240-26-4 C₁₇H₁₇F₂NO 
• 1415240-17-3 C₁₇H₁₉NO 

Relevant articles and documents

NOVEL COMPOUND HAVING HSP90 INHIBITORY ACTIVITY OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND MEDICAL USE THEREOF

The present invention relates to a novel compound having HSP90 inhibitory activity or a pharmaceutically acceptable salt thereof, and a medicinal use thereof, and composition comprising a dihydroxyphenyl compound or a benzamide compound, which is a novel compound having the HSP90 inhibitory activity of the present invention can effectively inhibit HSP90, and thus can be usefully used as a pharmaceutical composition for preventing or treating HSP90-mediated diseases or a health functional food for preventing or improving HSP90-mediated diseases, which selected from the group consisting of cancer diseases, degenerative neurological diseases and viral infections.

Selective Monomethylation of Amines with Methanol as the C1 Source

The N-monomethyl functionality is a common motif in a variety of synthetic and natural compounds. However, facile access to such compounds remains a fundamental challenge in organic synthesis owing to selectivity issues caused by overmethylation. To address this issue, we have developed a method for the selective, catalytic monomethylation of various structurally and functionally diverse amines, including typically problematic primary aliphatic amines, using methanol as the methylating agent, which is a sustainable chemical feedstock. Kinetic control of the aliphatic amine monomethylation was achieved by using a readily available ruthenium catalyst at an adequate temperature under hydrogen pressure. Various substrates including bio-related molecules and pharmaceuticals were selectively monomethylated, demonstrating the general utility of the developed method.

INDAZOLEPROPIONIC ACID AMIDE COMPOUND

Disclosed is a compound which is useful in preventing and treating cardiac arrhythmia such as atrial fibrillation. A compound represented by formula (1) or a pharmaceutically acceptable salt of the same. In formula (1), ring X represents benzene or pyridine; R1 represents an optionally substituted alkyl group; R2 represents an optionally substituted aryl group, an optionally substituted heterocyclic group, an optionally substituted arylalkyl group or an optionally substituted heterocyclic group-substituted alkyl group; R3, R4, R5, R6, R7, R8 and R9 represent each hydrogen or an alkyl group, provided that R3 and R5 may be bonded to each other to form, together with the carbon atom adjacent thereto, a cycloalkyl group; and m represents 0 or 1.