87401-32-9Relevant academic research and scientific papers
Bromoderivatives of gramines. Preparation and pharmacological properties
Franzone, Jose Sebastian,Cirillo, Rocco,Cravanzola, Carlo
, p. 261 - 268 (2007/10/02)
Bromination of gramine (I), 1-methylgramine (IX), 2-methylgramine (IV) and 1,2-dimethylgramine (XV) with different mole ratios of bromine to substrate was investigated; it was seen that the 5- and 6-position are the normal sites of bromination and 1-methylgramines (IX) and (XV) give better yields of bromoderivatives.Among the compounds submitted the pharmacological screening, 2,6-dibromo-1-methylgramine hydrobromide (Xa) and especially 6-bromo-2-methylgramine (V) showed a clear antiserotoninic antiinflammatory and analgesic activity.Furthermore gramine (V) showed a good anti prostaglandin synthetase activity in vitro.Key-words: Bromogramines. - Antiserotonic activity. - Antiinflammatory activity.
