874015-97-1Relevant academic research and scientific papers
Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions
Shue, Ho-Jane,Chen, Xiao,Schwerdt, John H.,Paliwal, Sunil,Blythin, David J.,Lin, Ling,Gu, Danlin,Wang, Cheng,Reichard, Gregory A.,Wang, Hongwu,Piwinski, John J.,Duffy, Ruth A.,Lachowicz, Jean E.,Coffin, Vicki L.,Nomeir, Amin A.,Morgan, Cynthia A.,Varty, Geoffrey B.,Shih, Neng-Yang
, p. 1065 - 1069 (2006)
A series of novel five-membered urea derivatives as potent NK1 receptor antagonists is described. The effects of substitution of a 4-fluoro group at the phenyl ring and the introduction of an α-methyl group at the benzylic position to improve p
