874136-23-9 Usage
Uses
Used in Pharmaceutical Development:
3-(tert-Butyl)-1-isopropyl-1H-pyrazol-5-aMine is used as a potential bioactive compound for its antitumor properties, making it a candidate for the development of new cancer treatments. Its ability to target and potentially inhibit the growth of tumor cells positions it as a valuable asset in the search for effective anticancer agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 3-(tert-Butyl)-1-isopropyl-1H-pyrazol-5-aMine is utilized as a building block in the synthesis of more complex molecules with therapeutic potential. Its unique structure allows for the creation of new compounds that can be further explored for their medicinal properties, including anti-inflammatory effects.
Used in Chemical Research:
3-(tert-Butyl)-1-isopropyl-1H-pyrazol-5-aMine serves as a valuable research tool in chemical laboratories. Its reactivity and structural features make it suitable for studying various chemical reactions and mechanisms, contributing to the advancement of chemical knowledge and the discovery of new synthetic pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 874136-23-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,4,1,3 and 6 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 874136-23:
(8*8)+(7*7)+(6*4)+(5*1)+(4*3)+(3*6)+(2*2)+(1*3)=179
179 % 10 = 9
So 874136-23-9 is a valid CAS Registry Number.
874136-23-9Relevant academic research and scientific papers
Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme
Rynearson, Kevin D.,Buckle, Ronald N.,Barnes, Keith D.,Herr, R. Jason,Mayhew, Nicholas J.,Paquette, William D.,Sakwa, Samuel A.,Nguyen, Phuong D.,Johnson, Graham,Tanzi, Rudolph E.,Wagner, Steven L.
supporting information, p. 3928 - 3937 (2016/08/01)
The design and construction of a series of novel aminothiazole-derived γ-secretase modulators is described. The incorporation of heterocyclic replacements of the terminal phenyl D-ring of lead compound 1 was conducted in order to align potency with favorable drug-like properties. γ-Secretase modulator 28 displayed good activity for in vitro inhibition of Aβ42, as well as substantial improvement in ADME and physicochemical properties, including aqueous solubility. Pharmacokinetic evaluation of compound 28 in mice revealed good brain penetration, as well as good clearance, half-life, and volume of distribution which collectively support the continued development of this class of compounds.
COMPOUNDS AND USES THEREOF IN MODULATING LEVELS OF VARIOUS AMYLOID BETA PEPTIDE ALLOFORMS
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Page/Page column 90, (2012/01/14)
The invention provides a novel compound having a structure corresponding to Formula (I): (A)-(B)-(C)-(D) or a pharmaceutically acceptable salt or prodrug thereof and methods for using them.
