29622-19-3

Basic information

• Product Name: rac-(R*)-2-Amino-3-(4-chlorophenyl)propionic acid ethyl ester
• Synonyms: 4-Chloro-DL-phenylalanine ethyl ester;rac-(R*)-2-Amino-3-(4-chlorophenyl)propionic acid ethyl ester
• CAS NO: 29622-19-3
• Molecular Formula: C₁₁H₁₄ClNO₂
• Molecular Weight: 227.69
• Mol File: 29622-19-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 312.2°C at 760 mmHg
• Flash Point: 142.6°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 0.000538mmHg at 25°C
• Refractive Index: 1.538
• CAS DataBase Reference: rac-(R*)-2-Amino-3-(4-chlorophenyl)propionic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: rac-(R*)-2-Amino-3-(4-chlorophenyl)propionic acid ethyl ester(29622-19-3)
• EPA Substance Registry System: rac-(R*)-2-Amino-3-(4-chlorophenyl)propionic acid ethyl ester(29622-19-3)

Safety Data

• Hazardous Substances Data: 29622-19-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H14ClNO2/c1-2-15-11(14)10(13)7-8-3-5-9(12)6-4-8/h3-6,10H,2,7,13H2,1H3/t10-/m0/s1

Upstream product

• 1353886-55-1 ethyl 3-(4-chlorophenyl)-2-(hydroxyimino)propionate 
• 6827-40-3 diethyl 4-chlorobenzylidenemalonate 
• 37556-13-1 diethyl (4-chlorobenzyl)malonate 
• 104-88-1 4-chlorobenzaldehyde 
• 1612831-73-8 (E)-ethyl 3-(4-chlorophenyl)-2-(hydroxyimino)propanoate 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 
• 140-88-5 ethyl acrylate 
• 64-17-5 ethanol 
• 7424-00-2 DL-Phe(4Cl) 

Downstream Products

• 875581-67-2 C₁₃H₁₆ClNO₃ 
• 874162-66-0 3-(4-chloro-phenyl)-2-diazo-propionic acid ethyl ester 
• 38964-54-4 L-4-chlorophenylalanine ethyl ester 
• 14173-39-8 p-chlorophenylalanine 
• 14091-08-8 para-Chloro-D-phenylalanine 
• 166449-97-4 D-4-chlorophenylalanine ethyl ester 

Relevant articles and documents

IMIDAZOPYRAZINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND THEIR USES AS LUCIFERINS

The present invention is in the field of bioluminescence in biology and/or medicine. In particular, the invention provides imidazopyrazine derivatives, processes for preparation thereof, and their uses as luciferins.

Pd-catalyzed directed ortho -C-H alkenylation of phenylalanine derivatives

A practical Pd-catalyzed ortho-olefination of enantioenriched N-(SO2Py)-protected aryl-alanine and norephedrine derivatives with electron-deficient alkenes has been developed using N-fluoro-2,4,6-trimethylpyridinium triflate as the terminal oxidant. The reaction occurs efficiently with excellent monosubstitution selectivity and without loss of enantiopurity. This cross-coupling proved to be broad in scope, tolerating a variety of steric and electronic changes to both coupling partners. Removal of the directing group under mild conditions provides access to optically active tetrahydroisoquinoline-3-carboxylic acid derivatives (Tics) with good diastereocontrol and with very small erosion of enantiomeric purity.

Resolution of N-protected amino acid esters using whole cells of Candida parapsilosis ATCC 7330

Whole cells of Candida parapsilosis ATCC 7330 were used for the resolution of N-acetyl amino acid esters. Excellent enantioselectivities (E = 40 to >500) were achieved for the resolution of N-protected protein and non-protein amino acid esters giving good yields (28-50%) and high enantiomeric excesses (up to >99%) for both enantiomers.