874186-98-8

Basic information

• Product Name: Pyridine-2-boronic acid pinacol ester
• Synonyms: 2-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE;Pyridine-2-boronic acid pinacol ester;Albb-006131;BP1166pyridine-2boronicacidpinacolester;2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, 2-(Pyridin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2-(2-pyridyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane;Pyridine, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;3-hydroxy-2,3-dimethylbutan-2-yl hydrogen pyridin-2-ylboronate
• CAS NO: 874186-98-8
• Molecular Formula: C11H18BNO3
• Molecular Weight: 223.08
• EINECS: 1533716-785-6
• Mol File: 874186-98-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 300.9 °C at 760 mmHg
• Flash Point: 135.8 °C
• Appearance: white to light yellow crystal powde
• Density: 1.03 g/cm³
• Vapor Pressure: 2E-05mmHg at 25°C
• Refractive Index: 1.501
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 5.26±0.19(Predicted)
• CAS DataBase Reference: Pyridine-2-boronic acid pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine-2-boronic acid pinacol ester(874186-98-8)
• EPA Substance Registry System: Pyridine-2-boronic acid pinacol ester(874186-98-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 874186-98-8(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow crystal powde

Uses

Pyridine-2-boronic Acid Pinacol Ester has been used as a reactant in the preparation of aminooxazoline azaxanthenes as oral β-secretase inhibitors to be used in Alzheimer''s therapy.

InChI:InChI=1/C11H16BNO2/c1-10(2,14)11(3,4)16-12(15)9-7-5-6-8-13-9/h5-8,14-15H,1-4H3

Upstream product

• 109-09-1 2-chloropyridine 
• 96649-78-4 2-(cyclohexyloxy)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 110-86-1 pyridine 
• 109-04-6 2-bromo-pyridine 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 73183-34-3 bis(pinacol)diborane 

Downstream Products

• 879088-41-2 4-chloro-3-(pyridin-2-yl)benzeneamine 
• 879088-40-1 2-(2-chloro-5-nitrophenyl)-pyridine 

Relevant articles and documents

Cationic magnesium hydride [MgH]+ stabilized by an NNNN-type macrocycle

A magnesium hydride cation [(L)MgH]+ supported by a macrocyclic ligand (L = Me4TACD; 1,4,7,10-tetramethyl-1,4,7,10-tetraazacyclododecane) has been prepared by partial protonolysis of a mixed amide hydride [(L)MgH2Mg{N(SiMe3)2}2] and shown to undergo a variety of reactions with unsaturated substrates, including pyridine.

2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors

A series of novel benzoxazole derivatives has been designed and shown to exhibit attractive JAK2 inhibitory profiles in biochemical and cellular assays, capable of delivering compounds with favorable PK properties in rats. Synthesis and structure-activity relationship data are also provided.

Process for the preparation of pyridine-2-boronic acid esters

Production of 2-pyridineboronic acid ester compounds (I) comprises reacting a 2-halopyridine compound (II) with a metallating reagent to form an organometallic compound (III), reacting (III) with a borate ester compound (IV) to form a complex salt (V), an