874202-29-6Relevant academic research and scientific papers
Regioselective synthesis of di-C-glycosylflavones possessing anti-inflammation activities
Shie, Jiun-Jie,Chen, Chih-An,Lin, Chih-Chien,Ku, Angela Fay,Cheng, Ting-Jen R.,Fang, Jim-Min,Wong, Chi-Huey
supporting information; experimental part, p. 4451 - 4462 (2010/11/05)
Three methods are utilized to synthesize a variety of 6,8-di-C- glycosylflavones bearing identical or distinct glycosyl moieties. Some C-glycosylation compounds are found to have better anti-inflammation activities than the parent flavones. Among them, 6,8-di-C-glucosylapigenin (known as vicenin-2) shows inhibition of TNF-α expression and NO production with IC50 values of 6.8 and 5.2 μM, respectively.
Total synthesis of (-)-episilvestrol and (-)-silvestrol
El Sous, Mariana,Khoo, Mui Ling,Holloway, Georgina,Owen, David,Scammells, Peter J.,Rizzacasa, Mark A.
, p. 7835 - 7838 (2008/09/18)
Sugar and spice... The total synthesis of the rare but potent anticancer natural product (-)-episilvestrol and its 5? epimer (-)-silvestrol was accompushed from D-glucose, naringenin, and methyl cinnamate (see scheme). The key steps of the sequence were inspired by the possible biogenesis of these compounds.
PROCESSES AND INTERMEDIATES
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Page/Page column 91; 92, (2010/02/15)
The present invention relates to synthetic processes for the preparation of compounds bearing a dioxanyl moiety, in particular to compounds bearing a dioxanyl side chain attached to a mono- or polycyclic core moiety, more particularly a cyclopentabenzofuran core moiety. The invention also relates to intermediate compounds used in these processes. Compounds which can be prepared by the process of the invention can be used as candidates for screening for potential therapeutic activity, thus the invention also relates to compounds obtainable or prepared by the methods described above, in particular to those having cytotoxic or cytostatic activity.
Development of a radioimmunoassay for the quantitative determination of 8-prenylnaringenin in biological matrices
Schaefer, Olaf,Bohlmann, Rolf,Schleuning, Wolf-Dieter,Schulze-Forster, Kai,Huempel, Michael
, p. 2881 - 2889 (2007/10/03)
Seven carboxylic acid haptens of 8-prenylnaringenin (8-PN) were synthesized, coupled to cationized bovine serum albumin, and employed to raise specific antisera in rabbits. Two linkers of different lengths (C 3H6COOH and C6/sub
