874210-29-4

Upstream product

• 52959-28-1 dimethyl 4,6-dihydroxyisophthalate 
• 72593-77-2 3,6,9-trioxadecyl bromide 
• 108-46-3 recorcinol 
• 19829-74-4 4,6-dihydroxyisophthalic acid 
• 62921-74-8 2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate 

Downstream Products

• 1250403-76-9 C₂₂H₃₈N₄O₁₀ 
• 936354-38-0 4,6-bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-N-(2-tritylsulfanyl-ethyl)-isophthalamic acid 
• 936354-31-3 C₆₄H₉₆N₆O₂₆ 
• 936352-81-7 C₅₆H₈₂N₄O₂₄ 
• 936347-09-0 (5-(methoxycarbonylmethylcarbamoyl)-2,4-bis{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}benzoylamino)acetic acid methyl ester 
• 492465-50-6 4,6-bis{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}isophthalic acid 
• 874210-38-5 4,6-bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-isophthalic acid monomethyl ester 
• 773866-29-8 4,6-bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-isophthaloyl dichloride 

Relevant academic research and scientific papers

Polyhydrazide-Based Organic Nanotubes as Efficient and Selective Artificial Iodide Channels

Reported herein is a series of pore-containing polymeric nanotubes based on a hydrogen-bonded hydrazide backbone. Nanotubes of suitable lengths, possessing a hollow cavity of about a 6.5 ? diameter, mediate highly efficient transport of diverse types of anions, rather than cations, across lipid membranes. The reported polymer channel, having an average molecular weight of 18.2 kDa and 3.6 nm in helical height, exhibits the highest anion-transport activities for iodide (EC50=0.042 μm or 0.028 mol % relative to lipid), whcih is transported 10 times more efficiently than chlorides (EC50=0.47 μm). Notably, even in cholesterol-rich environment, iodide transport activity remains high with an EC50 of 0.37 μm. Molecular dynamics simulation studies confirm that the channel is highly selective for anions and that such anion selectivity arises from a positive electrostatic potential of the central lumen rendered by the interior-pointing methyl groups.

Sequence-specific association in aqueous media by integrating hydrogen bonding and dynamic covalent interactions

Oligoamide strands that associate in a sequence-specific fashion into hydrogen-bonded duplexes in nonpolar solvents were converted into disulfide cross-linked duplexes in aqueous media. Thus, by incorporating trityl-protected thiol groups, which allows the reversible formation of disulfide bonds, into the oligoamide strands, only duplexes consisting of complementary hydrogen-bonding sequences were formed in aqueous solution as well as in methanol. The sequence-specific cross-linking of oligoamide strands was confirmed by MALDI-TOF, reverse-phase HPLC, and by isolating a cross-linked duplex. This study demonstrates that the sequence-specificity characteristic of multiply hydrogen-bonded systems can be extended into competitive media through the interplay of H-bonding and reversible covalent interactions, based on which a new class of molecular associating and ligating units that are compatible with both polar and nonpolar environments can be conveniently obtained. Copyright

Synthesis of crescent aromatic oligoamides

This article describes the synthetic procedures for the preparation of crescent (and helical) aromatic oligoamides developed in recent years in our laboratory. The large-scale preparation of a variety of monomers derived from various tetrasubstituted benzenes is presented. Three different strategies for constructing various oligomers consisting of meta- and meta/para-linked benzene residues are discussed. Factors affecting coupling efficiency and yields are analyzed. The developed synthetic methods have provided the basis for the preparation of longer oligomers and for the development of solid-phase synthesis.