874532-58-8Relevant academic research and scientific papers
Selective Monoarylation of Primary Amines Using the Pd-PEPPSI-IPentCl Precatalyst
Sharif, Sepideh,Rucker, Richard P.,Chandrasoma, Nalin,Mitchell, David,Rodriguez, Michael J.,Froese, Robert D. J.,Organ, Michael G.
supporting information, p. 9507 - 9511 (2015/08/11)
A single set of reaction conditions for the palladium-catalyzed amination of a wide variety of (hetero)aryl halides using primary alkyl amines has been developed. By combining the exceptionally high reactivity of the Pd-PEPPSI-IPentCl catalyst (PEPPSI=pyridine enhanced precatalyst preparation, stabilization, and initiation) with the soluble and nonaggressive sodium salt of BHT (BHT=2,6-di-tert-butyl-hydroxytoluene), both six- and five-membered (hetero)aryl halides undergo efficient and selective amination.
