874594-88-4Relevant articles and documents
Synthesis of pyrimidones and evaluation of their xanthine oxidase inhibitory and antioxidant activities
Gurupadaswamy, Handuvinahalli Devanna,Girish, Virupaksha,Zameer, Farhan,Hegdekatte, Raghavendra,Chauhan, Jyoti Bala,Khanum, Shaukath Ara
, p. 805 - 811 (2013)
The increasing prevalence of gout has been accompanied by a growing number of patients intolerant to or with disease refractory to the available urate-lowering therapies. This metabolic disease is a common disease with a higher prevalence in men older than 30 years and in women older than 50 years. These findings highlight the need for emerging treatments to effectively lower urate levels. In this view, we describe the xanthine oxidase (XO) inhibitory activities of the synthesized compounds 5a-j and also their antioxidant activities. Compounds 5c, 5d, 5f, 5h, and 5j exhibited good inhibitory activities against XO. On the other hand, compounds 5g and 5j exhibited moderate antioxidant activity. In order to find new urate-lowering compounds, the xanthine oxidase (XO) inhibitory and antioxidant activities of the newly synthesized pyrimidones 5a-j were evaluated. Compounds 5c, 5d, 5f, 5h, and 5j exhibited good inhibitory activities against XO. In addition, compounds 5g and 5j showed moderate antioxidant activity.
Anthracene-tethered aminomethyl oxadiazole chemosensor: A probe offering selective chromo- and fluorogenic signalings for targeting Cu(II)
Mashraqui, Sabir H.,Khan, Tabrez,Chandiramani, Mukesh,Betkar, Rupesh,Poonia, Kiran
experimental part, p. 361 - 367 (2011/11/29)
A new optical chemosensor featuring anthracene as a fluorophore and an aminomethyl oxadiazole moiety as a bidentate chelate has been synthesized. From photophysical studies, we find the probe to offer remarkably selective chromo- and fluorogenic signaling
