874655-85-3Relevant academic research and scientific papers
Ammonium chloride catalyzed Knoevenagel condensation in PEG-400 as ecofriendly solvent
Waghmare, Smita R.
, p. 849 - 855 (2021/09/28)
A simple and selective green methodology has been successfully developed for Knoevenagel condensation in polyethylene glycol-400 using 10 mol % ammonium chloride as catalyst. The method is applicable to a wide range of aromatic, heteroaromatic and α,β-unsaturated aldehydes. The reactions have been found to be clean and free from the formation of the Michael adduct.
Highly stereoselective synthesis of 1-cyanocyclopropane-carboxamides from 3-substituted-2-cyanoacrylamides with N-tosylhydrazones under metal-free conditions
Nie, Xufeng,Wang, Yachuan,Yang, Lijun,Yang, Zaijun,Kang, Tairan
supporting information, p. 3003 - 3007 (2017/07/17)
A metal-free cyclopropanation of electron-deficient olefins 3-substituted-2-cyanoacrylamides with N-tosylhydrazones has been successfully developed. This strategy provide a simple route to the synthesis of very valuable 1-cyanocyclopropanecarboxamides wit
Organocatalytic cascade reactions: Diversity-oriented synthesis for the construction of hydroisoquinoline scaffolds
Gómez, Clarisa Villegas,Cruz, David Cruz,Mose, Rasmus,J?rgensen, Karl Anker
supporting information, p. 6035 - 6038 (2014/05/20)
The organocatalytic enantioselective synthesis of highly functionalized hydroisoquinolines by trienamine-mediated [4+2]-cycloaddition/nucleophilic ring-closing reaction cascade sequence of cyanoacrylamides with 2,4-dienals is presented. The corresponding cycloadducts are formed in high yields and excellent stereoselectivities. Moreover, a series of transformations demonstrate the synthetic application of the obtained hydroisoquinolines. the Partner Organisations 2014.
