874660-58-9

Upstream product

• 874660-34-1 3-[(3aS,4R,6R,7aS)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-yl]-propan-1-ol 
• 100-39-0 benzyl bromide 
• 91376-49-7 (S)-1-(tert-butyldiphenylsilyloxy)-2-hydroxy-3-butene 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 106731-74-2 tert-butyl[(2S)-oxiran-2-ylmethoxy]diphenylsilane 
• 874660-57-8 ((3aS,4R,6R,7aS)-6-Allyl-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-ylmethoxy)-tert-butyl-diphenyl-silane 
• 874660-33-0 (3aS,4R,6R,7aS)-6-Allyl-4-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-[1,3]dioxolo[4,5-c]pyran-2-one 
• 874660-56-7 (2R,3S,4S,6R)-6-Allyl-2-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-pyran-3,4-diol 
• 874660-55-6 4-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethoxy-tetrahydro-[1,3]dioxolo[4,5-c]pyran-2-one 
• 874660-31-8 (2R,3S,4S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-6-ethoxy-tetrahydro-pyran-3,4-diol 
• 874660-28-3 tert-butyl-[2-(1-ethoxy-but-3-enyloxy)-but-3-enyloxy]-diphenyl-silane 
• 874660-54-5 tert-butyl-(6-ethoxy-5,6-dihydro-2H-pyran-2-ylmethoxy)-diphenyl-silane 

Downstream Products

• 874660-13-6 (3aS,4S,6R,7aS)-6-(3-Benzyloxy-propyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-carbaldehyde 
• 874660-59-0 [(3aS,4R,6R,7aS)-6-(3-Benzyloxy-propyl)-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-yl]-methanol 

Relevant academic research and scientific papers

Enantioselective total synthesis of brevetoxin A: convergent coupling strategy and completion

A highly convergent, enantioselective total synthesis of brevetoxin A is reported. The development of a [X+ 2+ X] Horner-Wadsworth-Emmons/ cyclodehydration/reductive etherification convergent coupling strategy allowed a unified approach to the synthesis o

Convergent, stereoselective synthesis of the GHIJ fragment of brevetoxin A

(Chemical Equation Presented) A stereoselective synthesis of the GHIJ fragment of brevetoxin A utilizing a convergent assembly strategy is described. Glycolate alkylation, ring-closing metathesis, and Hosomi-Sakurai reactions were central operations in the construction of the G ring and J ring subunits, which were united through a Horner-Wadsworth-Emmons coupling. Subsequent dehydrative cyclization produced an endocyclic enol ether that was further elaborated to the tetracyclic GHIJ fragment of brevetoxin A.