874752-02-0

Basic information

• Product Name: 2-(5-NITRO-1H-INDOL-2-YL)BENZOIC ACID
• Synonyms: 2-(5-NITRO-1H-INDOL-2-YL)BENZOIC ACID
• CAS NO: 874752-02-0
• Molecular Formula: C₁₅H₁₀N₂O₄
• Molecular Weight: 282.25
• Mol File: 874752-02-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(5-NITRO-1H-INDOL-2-YL)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-NITRO-1H-INDOL-2-YL)BENZOIC ACID(874752-02-0)
• EPA Substance Registry System: 2-(5-NITRO-1H-INDOL-2-YL)BENZOIC ACID(874752-02-0)

Safety Data

• Hazardous Substances Data: 874752-02-0(Hazardous Substances Data)

Usage

Chemical Class

Nonsteroidal anti-inflammatory drugs (NSAIDs)

Function

Inhibits the production of prostaglandins, which are responsible for pain and inflammation

Uses

Treats various inflammatory conditions such as arthritis, muscle pain, and menstrual cramps

Administration

Orally in the form of tablets or capsules

Side Effects

May cause stomach upset, headache, and dizziness

Precautions

Should be used with caution in individuals with a history of gastrointestinal disorders or bleeding.

Upstream product

• 512787-41-6 (5-nitro-1H-indol-1-yl)(phenyl)methanone 
• 65-85-0 benzoic acid 
• 6146-52-7 5-nitroindole 
• 874751-99-2 2-nitro-6H-isoindolo[2,1-α]indol-6-one 

Downstream Products

• 1059628-89-5 C₁₆H₁₂N₂O₄ 
• 874752-08-6 2-(2-azidomethyl-phenyl)-5-nitro-1H-indole 
• 874752-05-3 [2-(5-nitro-1H-indol-2-yl)-phenyl]-methanol 

Relevant articles and documents

Structure-activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pump in Staphylococcus aureus

The synthesis of 22 2-aryl-1H-indoles, including 12 new compounds, has been achieved via Pd- or Rh-mediated methodologies, or selective electrophilic substitution. All three methods were based on elaborations from simple indole precursors. SAR studies on

Synthesis of functionalised 2-aryl-5-nitro-1H-indoles and their activity as bacterial NorA efflux pump inhibitors

In order to develop structure-activity relationships and to provide access to antibacterial agents for dual action studies, a variety of aryl group-substituted 2-aryl-5-nitro-1H-indoles were synthesized and the activity of the compounds assessed as inhibitors of the NorA multidrug resistance pump in the bacterium Staphylococcus aureus. The NorA protein from the major facilitator superfamily of efflux pumps confers resistance to a variety of structurally dissimilar antimicrobials such as norfloxacin, ethidium bromide, berberine and acriflavin. The compound [4-benzyloxy-2-(5-nitro-1H-2-yl)-phenyl]-methanol was the most potent pump inhibitor.