874752-08-6 Usage
Indole ring
a core structure of the compound
2-(azidomethyl)phenyl group
attached at the 2-position of the indole ring
Nitro group
attached at the 5-position of the indole ring
Reactive moiety
azidomethyl group can be used for further chemical modifications
Participation in chemical reactions
nitro group can undergo various chemical reactions
Potential applications
organic synthesis and medicinal chemistry
Common structural motif
indole moiety is found in many bioactive compounds
Promising potential
for the development of new compounds with pharmaceutical or biological activity.
Check Digit Verification of cas no
The CAS Registry Mumber 874752-08-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,4,7,5 and 2 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 874752-08:
(8*8)+(7*7)+(6*4)+(5*7)+(4*5)+(3*2)+(2*0)+(1*8)=206
206 % 10 = 6
So 874752-08-6 is a valid CAS Registry Number.
874752-08-6Relevant articles and documents
Synthesis of functionalised 2-aryl-5-nitro-1H-indoles and their activity as bacterial NorA efflux pump inhibitors
Samosorn, Siritron,Bremner, John B.,Ball, Anthony,Lewis, Kim
, p. 857 - 865 (2007/10/03)
In order to develop structure-activity relationships and to provide access to antibacterial agents for dual action studies, a variety of aryl group-substituted 2-aryl-5-nitro-1H-indoles were synthesized and the activity of the compounds assessed as inhibitors of the NorA multidrug resistance pump in the bacterium Staphylococcus aureus. The NorA protein from the major facilitator superfamily of efflux pumps confers resistance to a variety of structurally dissimilar antimicrobials such as norfloxacin, ethidium bromide, berberine and acriflavin. The compound [4-benzyloxy-2-(5-nitro-1H-2-yl)-phenyl]-methanol was the most potent pump inhibitor.
