874817-14-8

Basic information

• Product Name: FMoc-D-serine Methyl ester
• Synonyms: FMoc-D-serine Methyl ester;D-Serine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, methyl ester
• CAS NO: 874817-14-8
• Molecular Formula: C₁₉H₁₉NO₅
• Molecular Weight: 341.35786
• Mol File: 874817-14-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 129-130 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))
• Boiling Point: 579.4±45.0 °C(Predicted)
• Appearance: /
• Density: 1.285±0.06 g/cm3(Predicted)
• PKA: 10.07±0.46(Predicted)
• CAS DataBase Reference: FMoc-D-serine Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: FMoc-D-serine Methyl ester(874817-14-8)
• EPA Substance Registry System: FMoc-D-serine Methyl ester(874817-14-8)

Safety Data

• Hazardous Substances Data: 874817-14-8(Hazardous Substances Data)

Usage

General Description

FMoc-D-serine Methyl ester is a chemical compound used in the process of peptide synthesis. It is a derivative of the amino acid D-serine, where the carboxyl group is protected with a fluorenylmethyloxycarbonyl (FMoc) group and the hydroxyl group is esterified with a methyl group. FMoc-D-serine Methyl ester is important in the creation of peptide chains due to its ability to act as a building block for the synthesis of peptides with specific sequences and properties. The FMoc group protects the carboxyl group, allowing for selective deprotection during the peptide synthesis process, and the methyl ester group serves as a temporary protector for the hydroxyl group, which can be removed under specific conditions. Overall, FMoc-D-serine Methyl ester plays a crucial role in the development and modification of peptides for various research and industrial applications.

Upstream product

• 67-56-1 methanol 
• 73724-45-5 (R)-N-(fluoren-9-ylmethoxycarbonyl)serine 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 5874-57-7 R-(-)-serine methyl ester hydrochloride 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 136083-72-2 N-(9-fluorenylmethoxycarbonyl)-DL-serine 
• 851678-66-5 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-hydroxypropionic acid methyl ester 
• 2104-89-4 D-serine methyl ester 

Downstream Products

• 874817-21-7 4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylic acid 9H-fluoren-9-ylmethyl ester 

Relevant articles and documents

Total Synthesis and Determination of the Absolute Configuration of Rakicidin C

The absolute configuration of rakicidin C was predicted by comparison of optical rotation data and absolute configuration of APD-cyclic depsipeptides and further determined by total synthesis. The absolute configuration of five chiral centers was determin

Highly Chemoselective Deprotection of the 2,2,2-Trichloroethoxycarbonyl (Troc) Protecting Group

Nonreducing, pH-neutral conditions for the selective cleavage of the 2,2,2-trichloroethoxycarbonyl (Troc) protecting group are reported. Using trimethyltin hydroxide in 1,2-dichloroethane, Troc-protected alcohols, thiols, and amines can be selectively unmasked in the presence of various functionalities that are incompatible with the reducing conditions traditionally used to remove the Troc group. This mild deprotection protocol tolerates a variety of other hydrolytically sensitive and acid/base-sensitive moieties as well.

An α-formylglycine building block for Fmoc-based solid-phase peptide synthesis

(Chemical Equation Presented) Nearly all known sulfatases share a common active site modification that is required for their activity: conversion of cysteine to α-formylglycine. We report the synthesis of an α-formylglycine building block suitable for Fmo