87486-33-7

Usage

Uses

Used in Pharmaceutical Industry:
1-Methyl-3,5-dichloro-2(1H)-pyrazinone is utilized as an intermediate in the synthesis of pharmaceuticals for its antimicrobial, antifungal, and other biological properties. It plays a significant role in the development of new drugs targeting a range of diseases and conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 1-Methyl-3,5-dichloro-2(1H)-pyrazinone is employed as an intermediate in the production of herbicides. Its herbicidal properties contribute to the development of effective weed control agents, enhancing agricultural productivity and crop protection.
As a Research and Development Target:
1-Methyl-3,5-dichloro-2(1H)-pyrazinone is an important subject of research and development within the fields of organic chemistry and chemical engineering. Its potential applications in pharmacology and agriculture make it a valuable compound for exploring new synthesis methods, applications, and improving existing ones.

Upstream product

• 79-37-8 oxalyl dichloride 
• 25808-30-4 2-(methylamino)acetonitrile hydrochloride 

Downstream Products

• 1343889-30-4 6'-сhloro-4'-methyl-4-(2-trifluoromethyl-benzoyl)-3,4,5,6-tetrahydro-2H,4'H-[1,2']bipyrazinyl-3'-one 
• 107363-56-4 1-(2-Bromo-phenyl)-3-[2-(6-chloro-4-methyl-3-oxo-3,4-dihydro-pyrazin-2-ylsulfanyl)-acetyl]-thiourea 
• 107363-53-1 1-[2-(6-Chloro-4-methyl-3-oxo-3,4-dihydro-pyrazin-2-ylsulfanyl)-acetyl]-3-(2-chloro-phenyl)-thiourea 
• 107363-54-2 1-[2-(6-Chloro-4-methyl-3-oxo-3,4-dihydro-pyrazin-2-ylsulfanyl)-acetyl]-3-(3-chloro-phenyl)-thiourea 
• 107363-51-9 1-[2-(6-Chloro-4-methyl-3-oxo-3,4-dihydro-pyrazin-2-ylsulfanyl)-acetyl]-3-phenyl-thiourea 
• 98078-22-9 5-Chloro-3-[5-(4-methoxy-phenyl)-3-methyl-pyrazol-1-yl]-1-methyl-1H-pyrazin-2-one 
• 98078-21-8 3-[5-(4-Bromo-phenyl)-3-methyl-pyrazol-1-yl]-5-chloro-1-methyl-1H-pyrazin-2-one 
• 98078-20-7 5-Chloro-3-[5-(4-chloro-phenyl)-3-methyl-pyrazol-1-yl]-1-methyl-1H-pyrazin-2-one 
• 98078-19-4 1-<5-chloro-1-methyl-2(1H)-pyrazin-2-on-3-yl>-5-phenyl-3-methylpyrazole 
• 87486-42-8 5-chloro-1,4-dihydro-1,4-dimethyl-2,3-pyrazinedione 
• 87486-40-6 5-Chloro-3-methoxy-1-methyl-2(1H)-pyrazinone 
• 130879-50-4 3-Chloro-1-methyl-5-phenyl-2(1H)-pyridone 
• 130879-49-1 3-Chloro-1-methyl-4-phenyl-2(1H)-pyridone 

Relevant academic research and scientific papers

PYRAZINE-2(1H)-KETONE COMPOUND ACTING AS FGFR INHIBITOR

Disclosed are a compound as shown in formula (I), and an isomer thereof or a pharmaceutically acceptable salt thereof, and involved is the use thereof in the preparation of drugs for treating FGFR-associated diseases.

NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A

The present invention relates to compounds of the formula (I), the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof. In formula I the variables Het, A, X, Y, Z, R1, R2, R3, R4, R5 and Q are as defined in the claims. The compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof are inhibitors of phosphodiesterase type 10A. Thus, the invention also relates to the use of the compounds of the formula I, the N-oxides, tautomers, the prodrugs and the pharmaceutically acceptable salts thereof for the manufacture of a medicament and which thus are suitable for treating or controlling of medical disorders selected from neurological disorders and psychiatric disorders, for ameliorating the symptoms associated with such disorders and for reducing the risk of such disorders.

NITROGEN HETEROCYCLE DERIVATIVES, PREPARATION THEREOF AND APPLICATION THEREOF IN HUMAN THERAPEUTICS

The present invention relates to compounds having general formula I characterised in that wherein in particular: R1 represents one or a plurality of groups such as: trifluoromethyl, halogen such as F, Cl, Br, methyl, nitro. R represents nitroge

N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS

The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I: which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.

Herbicidal 2-(1H)-pyrazinones

This invention relates to a novel class of 2-(1H)-pyrazinones and their use as herbicides and plant growth regulants.

A new synthesis of substituted 2(1H)-pyrazinones

The hydrohalides of 2-sec-aminoalkanenitriles on treatment with oxalyl halides in o-dichlorobenzene at 80-100° give 3,5-dihalo-2(1H)-pyrazinones, of which the 3-halo substituent is easily replaced by nucleophiles. A reaction mechanism for the pyrazinone s