874894-76-5

Upstream product

• 63-91-2 L-phenylalanine 
• 753487-59-1 (2S,3R)-3-methoxy-N-tert-butyl-N²-phthaloylphenylalanylamide 
• 32150-91-7 phthaloyl-L-phenylalanyl chloride 
• 5123-55-7 Nα-phthaloyl-L-phenylalanine 
• 160648-48-6 (2S,3R)-3-hydroxy-N-t-butyl-N^α-phthaloylphenylalaninamide 
• 874894-77-6 benzyl (1S,2R)-2-methoxy-1-(4'-methyl-2',6',7'-trioxabicyclo[2.2.2]-octan-1'-yl)-2-phenylethylcarbamate 
• 753488-03-8 2-amino-N-tert-butyl-3-methoxy-3-phenyl-propionamide 
• 135395-13-0 (S)-N-(tert-Butyl)-N^α-phthaloylphenylalaninamide 

Downstream Products

• 753487-55-7 (2S,3R)-N-(tert-butyloxycarbonyl)-3-methoxyphenylalanine 
• 753487-93-3 (S)-2-{[(S)-2-((2S,3R)-2-tert-Butoxycarbonylamino-3-methoxy-3-phenyl-propionylamino)-3-methyl-butyryl]-methyl-amino}-4-methyl-pentanoic acid allyl ester 
• 753487-75-1 (S)-2-{[(S)-2-((2S,3R)-2-Amino-3-methoxy-3-phenyl-propionylamino)-3-methyl-butyryl]-methyl-amino}-4-methyl-pentanoic acid allyl ester 
• 855315-37-6 (2S,3R)-N-(tert-butyloxycarbonyl)-3-methoxyphenylalanine methyl ester 
• 874894-83-4 (2S,3R)-2-Benzyloxycarbonylamino-3-methoxy-3-phenyl-propionic acid 2-trimethylsilanyl-ethyl ester 

Relevant academic research and scientific papers

A stereoselective synthesis of (2S,3R)-β-methoxyphenylalanine: A component of cyclomarin A

A stereoselective synthesis of (2S,3R)-β-methoxyphenylalanine, an amino acid contained within the cyclic peptide cyclomarin A, was successfully synthesized from Lajoie's serine aldehyde.

Total synthesis of cyclomarin C

The total synthesis of cyclomarin C was accomplished through a convergent strategy from a tetrapeptide fragment and a tripeptide one. The developed methods to prepare the needed noncoded amino acids, the proper protection of peptide fragments, and identification of the optimum macrocylization site can be applied to further synthetic studies on other members of cyclomarins.