874993-78-9

Upstream product

• 593-56-6 N-methoxylamine hydrochloride 
• 117607-26-8 1-<2-(4-morpholinyl)phenyl>ethanone 
• 23328-69-0 4-chloromorpholine 
• 3376-33-8 O-methyl acetophenone oxime 
• 1352619-55-6 d₅-acetophenone O-methyloxime 
• 98-86-2 acetophenone 

Downstream Products

• 1352619-33-0 C₁₃H₁₈N₂O₂*ClH 
• 1393678-61-9 dimethyl 2-(2-((E)-1-methoxyiminoethyl)-3-morpholinophenyl)malonate 
• 874993-79-0 1-(2-(4-morpholinyl)phenyl)ethylamine 

Relevant academic research and scientific papers

Rhodium(III)-catalyzed intermolecular direct amination of aromatic C-H bonds with N-chloroamines

A Rh(III)-catalyzed direct aromatic C-H amination is achieved using N-chloroamines as a reagent. Furthermore, we also developed a one-pot amination protocol involving in situ chlorination of the secondary amines. The catalytic amination operates at mild conditions with excellent functional group tolerance and regioselectivity.

Cyanoamidine P2X7 antagonists for the treatment of pain

Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R1-R12 are as defined in the specification act as antagonists of the P2X7 receptor. These compounds are particularly useful in the treatment of pain, inflammation and neurodegeneration states.