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Usage

Uses

Used in Pharmaceutical Industry:
5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one is used as a CDK8 inhibitor for the treatment of cancer. CDK8, a cyclin-dependent kinase, plays a crucial role in the regulation of cell cycle progression and transcription. Its overexpression has been associated with various types of cancer, making it a promising target for therapeutic intervention. By inhibiting CDK8, 5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one can potentially disrupt the abnormal cell cycle and transcriptional regulation in cancer cells, leading to the suppression of tumor growth and progression. This application highlights its potential as a targeted cancer therapy agent, offering a more specific and potentially less toxic treatment option for patients.

Upstream product

• 13861-75-1 spiro[cyclopropane-1,3'-indolin]-2'-one 
• 30015-90-8 spiro<3H-indol-3,2'-oxiran>-2(1H)-one 
• 91-56-5 indole-2,3-dione 
• 20870-78-4 5-bromo-2-indolin-2-one 
• 247129-85-7 (2-bromoethyl)(diphenyl)sulfonium trifluoromethanesulfonate 
• 106-93-4 ethylene dibromide 
• 59-48-3 2-oxoindole 

Downstream Products

• 1613639-40-9 spiro(cyclopropane-1,3-indolin)-2-one-5-boronic acid pinacol ester 
• 1613638-66-6 (R)-5‘-(5-((2-hydroxy-1-phenylethyl)amino)pyridin-3-yl)spiro[cyclopropane-1,3‘-indolin]-2’-one 

Relevant academic research and scientific papers

Compound serving as thyroid hormone beta receptor agonist and use thereof

The invention relates to a compound serving as a thyroid hormone beta receptor agonist and use thereof, and further relates to a pharmaceutical composition containing the compound. The compound or thepharmaceutical composition can be used for preparing a

A convenient cyclopropanation process of oxindoles via bromoethylsulfonium salt

A practical convenient conversion of oxindoles into the corresponding spirocyclopropyl oxindoles is achieved efficiently using bromoethylsulfonium salt, which is easily prepared on a large scale and is stable crystalline. This reaction of bromoethylsulfonium salt with different substituted unprotected oxindoles proceeded under mild condition and provided moderate yields.

Domino Corey-Chaykovsky Reaction for One-Pot Access to Spirocyclopropyl Oxindoles

The development of the sequential Corey-Chaykovsky reactions of isatins, spiroepoxy-, or spiroaziridine oxindoles with sulfur ylide has led to the discovery of a unique reaction mode that allows easy and direct one-pot access to a range of spirocyclopropyl oxindoles.

Progesterone receptor modulators comprising pyrrole-oxindole derivatives and uses thereof

Pyrrole-oxindole derivatives useful as progesterone receptor antagonists are provided. Pharmaceutical compositions containing these derivatives are described, as is the use thereof in contraception and hormone-related conditions.

New progesterone receptor antagonists: 3,3-disubstituted-5-aryloxindoles.

A new series of 3,3-disubstituted-5-aryloxindoles has been synthesized and evaluated for progesterone receptor antagonist (PR) activity in a T47D cell alkaline phosphatase assay and for their ability to bind PR in competition binding studies. In this comm