875071-97-9 Usage
Description
5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one is a chemical compound that features a unique spiro structure consisting of a cyclopropane and indolin moiety, with a bromine atom attached at the 5' position. This structural arrangement endows it with specific properties that make it a candidate for pharmaceutical applications, particularly in the development of targeted therapies.
Uses
Used in Pharmaceutical Industry:
5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one is used as a CDK8 inhibitor for the treatment of cancer. CDK8, a cyclin-dependent kinase, plays a crucial role in the regulation of cell cycle progression and transcription. Its overexpression has been associated with various types of cancer, making it a promising target for therapeutic intervention. By inhibiting CDK8, 5'-Bromospiro[cyclopropane-1,3'-indolin]-2'-one can potentially disrupt the abnormal cell cycle and transcriptional regulation in cancer cells, leading to the suppression of tumor growth and progression. This application highlights its potential as a targeted cancer therapy agent, offering a more specific and potentially less toxic treatment option for patients.
Check Digit Verification of cas no
The CAS Registry Mumber 875071-97-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,5,0,7 and 1 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 875071-97:
(8*8)+(7*7)+(6*5)+(5*0)+(4*7)+(3*1)+(2*9)+(1*7)=199
199 % 10 = 9
So 875071-97-9 is a valid CAS Registry Number.
875071-97-9Relevant articles and documents
Compound serving as thyroid hormone beta receptor agonist and use thereof
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Paragraph 0251-0255, (2021/02/10)
The invention relates to a compound serving as a thyroid hormone beta receptor agonist and use thereof, and further relates to a pharmaceutical composition containing the compound. The compound or thepharmaceutical composition can be used for preparing a
Domino Corey-Chaykovsky Reaction for One-Pot Access to Spirocyclopropyl Oxindoles
Hajra, Saumen,Roy, Sayan,Saleh, S.K. Abu
, p. 4540 - 4544 (2018/08/07)
The development of the sequential Corey-Chaykovsky reactions of isatins, spiroepoxy-, or spiroaziridine oxindoles with sulfur ylide has led to the discovery of a unique reaction mode that allows easy and direct one-pot access to a range of spirocyclopropyl oxindoles.
New progesterone receptor antagonists: 3,3-disubstituted-5-aryloxindoles.
Fensome, Andrew,Bender, Reinhold,Cohen, Jeffrey,Collins, Mark A,Mackner, Valerie A,Miller, Lori L,Ullrich, John W,Winneker, Richard,Wrobel, Jay,Zhang, Puwen,Zhang, Zhiming,Zhu, Yuan
, p. 3487 - 3490 (2007/10/03)
A new series of 3,3-disubstituted-5-aryloxindoles has been synthesized and evaluated for progesterone receptor antagonist (PR) activity in a T47D cell alkaline phosphatase assay and for their ability to bind PR in competition binding studies. In this comm
