875145-49-6

Basic information

• Product Name: Benzoic acid, 4-(acetylamino)-2-fluoro-3-methyl-
• CAS NO: 875145-49-6
• Molecular Formula: C10H10FNO3
• Molecular Weight: 211.193
• Mol File: 875145-49-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-(acetylamino)-2-fluoro-3-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(acetylamino)-2-fluoro-3-methyl-(875145-49-6)
• EPA Substance Registry System: Benzoic acid, 4-(acetylamino)-2-fluoro-3-methyl-(875145-49-6)

Safety Data

• Hazardous Substances Data: 875145-49-6(Hazardous Substances Data)

Upstream product

• 443-86-7 3-fluoro-2-methylaniline 
• 875145-55-4 2-fluoro-3-methyl-4-(acetyl)aminophenyl iodide 
• 124-38-9 carbon dioxide 
• 329927-16-4 2-fluoro-3-methyl-4-aminophenyl iodide 

Downstream Products

• 1364740-54-4 C₂₂H₁₃ClF₅NO₃ 
• 1364740-36-2 C₂₄H₁₃ClF₅NO₄ 
• 194804-84-7 2-fluoro-3-methyl-4-aminobenzoic acid 

Relevant articles and documents

Practical synthesis of a benzophenone-based NNRT inhibitor of HIV-1

A convergent synthesis of NNRTI 1 is described. The key step involves a direct coupling of acid chloride 4 with Grignard reagent 11 in the presence of bis[2-(N,N-dimethylamino)ethyl] ether that moderates the reactivity of the Grignard reagent to give benzophenone 7. An efficient 2-step process for the preparation of 2-fluoro-3-methyl-4-aminobenzoic acid (3) is also described.