875241-67-1

Basic information

• Product Name: 2-methoxy-1-nitro-4-phenoxy-benzene
• Synonyms: 2-methoxy-1-nitro-4-phenoxy-benzene
• CAS NO: 875241-67-1
• Molecular Weight: 245.235
• Mol File: 875241-67-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-methoxy-1-nitro-4-phenoxy-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methoxy-1-nitro-4-phenoxy-benzene(875241-67-1)
• EPA Substance Registry System: 2-methoxy-1-nitro-4-phenoxy-benzene(875241-67-1)

Safety Data

• Hazardous Substances Data: 875241-67-1(Hazardous Substances Data)

Upstream product

• 1655-68-1 1-methoxy-3-phenoxybenzene 
• 64-19-7 acetic acid 
• 448-19-1 4-fluoro-2-methoxy-1-nitrobenzene 
• 108-95-2 phenol 
• 103966-66-1 4-bromo-2-methoxy-1-nitro-benzene 
• 100-67-4 potassium phenolate 
• 6627-53-8 1-chloro-3-methoxy-4-nitrobenzene 

Downstream Products

• 267416-80-8 2-methoxy-4-phenoxy-phenylamine 

Relevant articles and documents

Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents

Hypertension is an important target for drug discovery. We have focused on the with-no-lysine kinase (WNK)-oxidative stress-responsive 1 (OSR1) and STE20/SPS1-related proline-alanine-rich protein kinase (SPAK)-NaCl cotransporter (NCC) signal cascade as a potential target, and we previously developed a screening system for inhibitors of WNK-OSR1/SPAK-NCC signaling. Herein we used this system to examine the structure-activity relationship (SAR) of salicylanilide derivatives as SPAK kinase inhibitors. Structural design and development based on our previous hit compound, aryloxybenzanilide derivative 2, and the veterinary anthelmintic closantel (3) led to the discovery of compound 10 a as a potent SPAK inhibitor with reduced toxicity. Compound 10 a decreased the phosphorylation level of NCC in mouse kidney in vivo, and appears to be a promising lead compound for a new class of antihypertensive drugs.

Structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK inhibitors blocking WNK kinase signaling

We report here structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK (STE20/SPS1-related proline/alanine-rich kinase) inhibitors. Abnormal activation of the signal cascade of with-no-lysine kinase (WNK) with OSR1 (oxidative stress-responsive kinase 1)/SPAK and NCC (NaCl cotransporter) results in characteristic salt-sensitive hypertension, and therefore inhibitors of the WNK-OSR1/SPAK-NCC cascade are candidates for antihypertensive drugs. Based on the structure of lead compound 2, we examined the SAR of N-(4-phenoxyphenyl)benzamide derivatives, and developed compound 20l as a potent SPAK inhibitor. Compounds 20l is a promising candidate for a new class of antihypertensive drugs.

INHIBITORS OF BRUTON'S TYROSINE KINASE

This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.