875271-89-9Relevant academic research and scientific papers
SMALL-MOLECULE BOTULINUM TOXIN INHIBITORS
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Page/Page column 16, (2010/11/03)
Small-molecule inhibitors of Botulinum toxin, including BoNTA, BoNTD and BoNTE are provided, as well as methods of using the inhibitors.
Serotype-selective, small-molecule inhibitors of the zinc endopeptidase of botulinum neurotoxin serotype A
Park, Jewn Giew,Sill, Peter C.,Makiyi, Edward F.,Garcia-Sosa, Alfonso T.,Millard, Charles B.,Schmidt, James J.,Pang, Yuan-Ping
, p. 395 - 408 (2007/10/03)
Botulinum neurotoxin serotype A (BoNTA) is one of the most toxic substances known. Currently, there is no antidote to BoNTA. Small molecules identified from high-throughput screening reportedly inhibit the endopeptidase-the zinc-bound, catalytic domain of
