875289-87-5

Upstream product

• 69673-92-3 α-chloro-4-methyl propiophenone 
• 333-20-0 potassium thioacyanate 
• 5337-93-9 4'-methylpropiophenone 
• 540-72-7 sodium thiocyanide 
• 7677-24-9 trimethylsilyl cyanide 
• 92821-88-0 2-bromo-4'-methylpropiophenone 

Downstream Products

• 91349-32-5 2-chloro-5-methyl-4-p-tolyl-thiazole 
• 92287-62-2 5-methyl-4-p-tolyl-3H-thiazol-2-one 

Relevant academic research and scientific papers

α-Selective C(sp3)-H Thio/Selenocyanation of Ketones with Elemental Chalcogen

A facile method is disclosed for the synthesis of α-thio/selenocyanato ketones through regioselective C-H thio/selenocyanation of ketones. The advantages include the use of easily available starting materials, high efficiency, simple operation, and easy scale-up. Control experiments provide evidence that the reaction proceeded via a radical way, while kinetic isotope effect experiments reveal that the cleavage of the C-H bond serves as the rate-limiting step.

Redox Active Sodium Iodide/Recyclable Heterogeneous Solid Acid: An Efficient Dual Catalytic System for Electrochemically Oxidative α-C?H Thiocyanation and Sulfenylation of Ketones

An efficient electrochemically oxidative α-C?H thiocyanation and sulfenylation of ketones has been developed in a simple undivided cell under constant current condition.?The electrochemistry performs using NaI as the redox catalyst and heterogeneous solid salt Amberlyst-15(H) (A-15(H)) as proton catalyst?without the addition of external conductive salts. The protocol proved to be practical since the solid salt could be reused in up to five consecutive gram-scale runs without significant decrease in efficiency. Control experiments and cyclic voltammetry analysis disclose that the reaction proceeds likely via a cascade α-halogenation and subsequent thiocyanation or sulfenylation. (Figure presented.).